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Novel Repeat Elements for Genome Analysis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29275
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29275
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Genaissance Pharmaceuticals
Five Science Park New Haven, CT 06511
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Novel Repeat Elements for Genome Analysis
Agency: HHS
Contract: 1 R43 CA71315-01,
Award Amount: $96,792.00
 

Abstract:

The goal of this Phase I project is to isolate and characterize new chromosome-specific human repetelements. The resulting probes will be valuable for cytogenetic cancer diagnostics. Our preliminaryrandom amplification of polymorphic DNA (RAPD) is a valuable approach for the discovery of chromosompolymorphic repetitive DNA elements. Phase I will involve systematic and high- throughput employmentgenome-wide search for such elements. The repetitive DNAs will be cloned, then characterized by sequchromosomal localization and sublocalization, heterozygosity determination, evaluation of evolutionadetermination of average copy number. Additionally, Phase I will include modeling cytogenetic analyschromosomal aberrations using chromosome-specific repetitive DNA probes. Our model system will emplorepetitive element mapping to chromosome 20q12, which we discovered in preliminary research using RAprobe in interphase nuclei representing specific hematological malignancies known to have chromosomavicinity

Principal Investigator:

Wan-Liang Li
20373

Business Contact:

Small Business Information at Submission:

Bios Laboratorytories, Inc.
5 Science Park New Haven, CT 06511

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No