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Ultra-Sensitive Detection of Protein-Ligand Interactions

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65391
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA101460
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIOSENSE TECHNOLOGIES, INC.
4 ARROW DR WOBURN, MA 01801-2040
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Ultra-Sensitive Detection of Protein-Ligand Interactions
Agency: HHS
Contract: 1R43CA101460-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The development of an evanescent wave biosensor enabling the monitoring of binding interactions of small weakly interacting bio-molecules (MW<100Da) currently not possible is proposed. This technique relies on an innovative transducer design employing a novel self-compensating interferometer capable of surface sensitivities at the level of fg/mm2 - many orders of magnitude improvement over commercially available biosensors. The device employs the novel use of microfluidic flow dynamics for high capture efficiency further reducing the time to results for high throughput and is readily integrated into a small disposable, sealed cartridge for ease of use and low cost. The Phase I effort is focused around a proof-of-principle experiment demonstrating the sensitivity of the device. The Phase II effort will focus on the development of a microfluidic flow cell and a technical demonstration of the binding of a relevant ligand-protein system.

Principal Investigator:

Ronald J. Rieder
7819333635
RIEDER@BIOSENSETECH.COM

Business Contact:


7819333635
Small Business Information at Submission:

BIOSENSE TECHNOLOGIES, INC.
BIOSENSE TECHNOLOGIES, INC. 4 ARROW DR WOBURN, MA 01801

EIN/Tax ID: 510423778
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No