The goal of phase i is to determine the usefulness of a new separation technique for the rapid isolation of aflatoxins from food commodities such as milk and grain solvent extracts. the separation technique termed electromolecular propulsion (emp) by its inventor norman haber will be evaluated with… More

Phase i will involve ascertaining the feasibility of a novel electrochemical immunosensor approach. electrodes in series and with electroactive reagents will be constructed and evaluated for their ability to detect haptens and antigens such as aflatoxin b1 and htlv-iii. an electrochemical… More

Recombinant dna techniques will be used to produce a subunit vaccine for aids which will resemble the outer membranes of htlv-iii virions or htlv-iii infected cells. a recombinant dna vector will be constructed to contain the env region of the virus along with the 5 and 3 ltr's which are required… More

For the past 40 years, clinical immune globulin and albumin have been isolated from plasma or cryosupernatant by the cold ethanol procedure throughout the world. because of the excellent records of safety and efficacy of these two products, it is safe to assume that, in the foreseeable future, the… More

Nih researchers have recently announced the isolation of a human b-lymphotropic virus (hblv) from six individuals with various lymphoproliferative and immune disorders. hblv appears to belong to the group of human herpes viruses and may be associated with b lymphoproliferative disorders. early… More

A novel human b-lymphotropic virus (hblv) has been recently isolated from patients with lymphoproliferative disorders. this herpes virus has been shown to infect b and t lymphocytes and to alter their morphology and growth characteristics. the significance of the virus in causing human diseases has… More

A model vaccine system will be developed using recombinant dna technology and classic virology to construct a nondefective recombinant adenovirus that expresses the simian immunodeficiency virus (siv) envelope protein. vaccination of rhesus macaques with the recombinant siv-adenovirus and subsequent… More

Phase i research iill develop a prototype elisa antigen-capture kit to measure htlv-i core proteins p19 and p24 produced during virus replication in cells. htlv-i is linked to the development of adult t-cell leukemia and totropical spastic paraparesis, a neurological disease of interest to… More

The treatment of lyme disease could be greatly enhanced if it were possible to detect the lyme disease spirochete directly in blood with a highly sensitive test. it is planned to develop a test where a region of the borrelia burgdorferi ospa gene is amplified using the polymerase chain reaction… More

Not Available Triton Systems proposes to combine its innovative polymer-clay nanotechnology with chemically resistant polymers to develop revolutionary flexible nanocomposite materials that will provide significant performance improvements and also reduce the cost of chemical and biological (CB)… More

Not Available This Small Innovative Research Phase I proposal seeks to employ a new phenomena, high pressure electrokinetic (HPEK) pumping, for the development of embedded electronically activated actuator assemblies. The Phase I research will demonstrate the ability to obtain controlled, high… More

Not Available The Advanced Analysis Package for High Speed Multi-Bearing Shaft Systems for rolling bearing supported rotors has Unique Features and Capabilities typical of industries current design needs. Among these are loosely coupled interfaces with commercial FEA c

An application using pressure cycling technology (PCT) is being developed to lyse cells and homogenize tissues for automated biological sample processing. This technology is feasible for automated processes in both low and high throughput applications. Our Phase I study… More

An application using pressure cycling technology (PCT) is being developed to lyse cells and homogenize tissues for automated biological sample processing. This technology is feasible for automated processes in both low and high throughput applications. Our Phase I study… More

DESCRIPTION (provided by applicant): This proposal describes the feasibility study of using Boston Biomedica, Inc.'s proprietary Pressure Cycling Technology (PCT), its instrument (Barocylcer) and its novel sample preparation tube (PULSE) to process sputum and Mycobacteria species for detection by… More

Prion diseases are 100 percent fatal, there is no treatment available, and cannot be diagnosed prior to the occurrence of symptoms. There is a public health need and an enormous market for a screening test that can help protect the blood supply, screen live animals, and ensure food safety. We… More

DESCRIPTION (provided by applicant): Some epidemiological studies are so large that it would be too expensive to isolate peripheral blood mononuclear cells (PBMCs) from every donor enrolled in them. Therefore, research studies, such as the Retrovirus Epidemiology Donors Study (REDS) have collected… More

DESCRIPTION (provided by investigator): This application describes the feasibility study of using Boston Biomedica, Inc.'s proprietary Pressure Cycling Technology (PCT), its instrument (BarocylcerTM) and its novel sample preparation tube (PULSE) as a new method to collect, transport, store, grow… More