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DETECTION OF PRION PROTEIN IN BLOOD

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
61148
Program Year/Program:
2002 / STTR
Agency Tracking Number:
NS043884
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SERACARE LIFE SCIENCES, INC.
SERACARE LIFE SCIENCES, INC. 1935 AVENIDA DEL ORO, STE F OCEANSIDE, MD 92056 0582
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: DETECTION OF PRION PROTEIN IN BLOOD
Agency: HHS
Contract: 1R41NS043884-01
Award Amount: $123,566.00
 

Abstract:

Prion diseases are 100 percent fatal, there is no treatment available, and cannot be diagnosed prior to the occurrence of symptoms. There is a public health need and an enormous market for a screening test that can help protect the blood supply, screen live animals, and ensure food safety. We propose to develop and validate an innovative, highly sensitive screening method for the detection of the infectious prion protein in the blood of humans and animals. We have selected an amplification-boosted analytical method, immuno-polymerase chain reaction (I-PCR) that utilizes an amplifiable DNA-label coupled to a specific antibody, and combines serologic and molecular diagnostic potentials to amplify micro quantities of protein to detectable levels; the method's unparalleled sensitivity in the sub-femtogram range meets the criterion proposed for detection of prion in blood. Recombinant phage antibodies will be produced and used as specific reagents. Preliminary results have shown proof of concept that IPCR method has the needed sensitivity. The strengths include: (1) a scientific group with expertise in diagnostics and product development, (2) the selection of a highly sensitive analytical approach and novel detection probes, and (3) a strong business partner having expertise in translating prototype assays into sensitive, specific, and reproducible products.

Principal Investigator:

Jiuping J. Ji
3012088100
jji@bbi.com

Business Contact:

Mark Manak
3012088100
MMANAK@BBII.COM
Small Business Information at Submission:

BIOTECH RESEARCH LABORATORIES (BTRL)
BIOTECH RESEARCH LABORATORIES 217 PERRY PKY GAITHERSBURG, MD 20877

EIN/Tax ID: 043152484
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF MARYLAND
UMD
Baltimore, MD 21201
RI Type: Nonprofit college or university