USA flag logo/image

An Official Website of the United States Government

Digital Wireless Recording of Wideband Neuronal Activity in Freely-Moving Humans

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85916
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
NS057839
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIO-SIGNAL GROUP CORPORATION
SUNY DOWNSTATE MEDICAL CENTER BOX 1247 NEW YORK, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Digital Wireless Recording of Wideband Neuronal Activity in Freely-Moving Humans
Agency: HHS
Contract: 1R43NS057839-01
Award Amount: $152,262.00
 

Abstract:

DESCRIPTION (provided by applicant): Bio-Signal Group Corp. developed a miniature, low-power, wireless digital recording technology called digital telemetry (DT) for recording wideband neural signals in rats. DT is wireless, allowing the subject to move fr eely within 10 m of a receiver. DT digitizes neural signals at the electrode connector to avoid inductive noise pickup from movements, other people and signal transmission through changing ambient electrical fields. Compared to conventional 12-bit systems, DT digitizes small fast action potentials and large slow brain field potentials at 24-bit (4096 times greater) resolution making it unnecessary to separately filter the two signal bands. This allows the phase relations in action (single cell) and field (p opulation) potentials to be captured without unrecoverable distortions. These (and additional) innovations of DT can overcome the technical barrier to recording wideband brain signals from moving and seizing epileptic patients. In collaboration with the Se izures Disorder Center at UCLA, we will 1) develop a user- interface for remote configuration of the on-subject transmitter; 2) make previously impossible recordings of wideband signals during movement, convulsive intra-ictal events, and post-ictal agitati on; and 3) test in people whether the covariance of action potentials and fast field oscillations indexes the likelihood and origin of seizure. There are many good reasons to study how activity from individual neurons is organized into brain networks, and how the recruitment of individual neurons into synchronized population activity might underlie seizure and its cognitive consequences. Although electrode and surgical technology has advanced so wideband (field and action potentials) brain signals can be re corded using depth electrodes implanted in the brains of awake freely-behaving human epileptic patients, artifact-free recordings during movements and peri-ictal events cannot be made because of limitations in the required biomedical electronics.

Principal Investigator:

James G. Donnett
6462574028
JDONNETT@BIOSIGNALGROUP.COM

Business Contact:

John Gridley
jgridley@biosignalgroup.com
Small Business Information at Submission:

BIO-SIGNAL GROUP CORPORATION
SUNY DOWNSTATE MEDICAL CENTER BOX 1247 NEW YORK, NY 11203

EIN/Tax ID: 522377842
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No