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SIMULTANEOUS DETECTION OF MULTIPLE DISEASE STATES

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
9507
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
9507
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biostar Medical Products, Inc
5766 Central Avenue Boulder, CO 80301
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: SIMULTANEOUS DETECTION OF MULTIPLE DISEASE STATES
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $49,657.00
 

Abstract:

BIO-STAR PROPOSES TO DEVELOP A SOLID PHASE ASSAY FOR THE SIMULTANEOUS DETECTION OF THREE OR MORE ANALYTES (ANTIGENS AND/OR ANTIBODIES), USING AN OPTICAL INTERFERENCE SIGNAL. THIS OPTICAL IMMUNOASSAY (OIA) IS A TECHNIQUE FOR THE DIRECT PHYSICAL DETECTION OF THE IMMUNOCHEMICAL REACTION AND GENERALLY DOES NOT REQUIRE THE USE OF ANY ADDED REAGENTS. THE SIGNAL CAN BE DETECTED WITH THE UNAIDED EYE, OR WITH A REFLECTOMETER OR ELLIPSOMETER FOR QUANTIFICATION. EACH ASSAY WILL BE CONDUCTED ON A DISTINCT REACTION ZONE ON THE SLIDE. WE PROPOSE TO CONVERT THREE ELISA TESTS INTO THE OIA FORMAT DURING PHASE I. THESE TESTS DETECT THE PRESENCE OF ANTIBODIES ASSOCIATED WITH AUTOIMMUNE DISEASES. WE WILL DEMONSTRATE THE ABILITY TO IMMOBILIZE THREE DISTINCT CLASSES OF MOLECULES ON OUR SUBSTRATE, AND TO GENERATE A DETECTABLE SIGNAL WITH OIA. IN PHASE II WE WILL BUILD THE FINAL TRI-ANALYTE PROTOTYPE, THEN USE THIS ASSAY DEVELOPMENT EXPERIENCE TO DESIGN A TRI-ANALYTE TEST FOR THREE DISEASES OF MILITARY SIGNIFICANCE.THE FINAL TEST WILL BE SENSITIVE, RAPID, AND SUITABLE FOR USE IN BOTH LABORATORY AND FIELD ENVIRONMENTS. THE FLEXIBILITY AND SIMPLICITY OF THE OIA FORMAT MAKES THIS TECHNOLOGY IDEALLY SUITED TO THE DEVELOPMENT OF TRI-ANALYTE IMMUNOASSAYS.

Principal Investigator:

Dr Luis Lopez
3034471605

Business Contact:

Small Business Information at Submission:

Bio-star Medical Products Inc
5766 Central Ave Boulder, CO 80301

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No