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POROUS MICROCARRIERS FOR GROWING CELL CULTURES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3184
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
3184
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biotech Research Laboratory
3 Taft Court Rockville, MD 20850
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: POROUS MICROCARRIERS FOR GROWING CELL CULTURES
Agency: HHS
Contract: N/A
Award Amount: $242,000.00
 

Abstract:

THE OVERALL OBJECTIVE OF THIS PROGRAM IS TO DEVELOP COST-EFFECTIVE TECHNOLOGY FOR THE SCALE-UP OF MAMMALIAN CELL CULTURE FOR THE MANUFACTURE OF PRODUCTS SUCH AS MONOCLONAL ANTIBODIES OR GENETICALLY ENGINEERED PROTEINS. THE APPROACH INVOLVES GROWTH OF CELLS IN THE INTERSTICES OF A POROUS MATRIX, PROVIDING MECHANICAL PROTECTION FOR THE CELLS AS WELL AS A MEANS TO RETAIN AND CONCENTRATE THEM SO THAT HIGHER CELL DENSITIES CAN BE REACHED. THE ADVANTAGES OF THIS APPROACH INCLUDE COMPATIBILITY WITH EXISTING CULTURE HARDWARE AND PROCEDURES, EASE OF SCALE-UP, HIGHER CELL DENSITY, SIMPLIFIED CONTROL, AND NEW OPPORTUNITIES TO OPTIMIZE THE METABOLISM OF THE CELLS TO MAXIMIZE PRODUCT YIELD. THE SPECIFIC COMMERCIAL OBJECTIVE OF PHASE I RESEARCH IS TO DEVELOP A SUITABLE MATRIX MATERIAL AND DEMONSTRATE ITS POTENTIAL UTILITY FOR CELL CULTURE OF ANCHORAGE-INDEPENDENT CELLS. PHASE I RESEARCH WILL STUDY MATRIX-CELL INTERACTIONS WITH LABORATORY SCALE METHODOLOGY USING LOW MATRIX CONCENTRATIONS IN THE CULTURE, WHICH WILL ALLOW THE MATRIX-CELL INTERACTIONS TO BE STUDIED IN THE ABSENCE OF LIMITATIONS OF OXYGENATION OR EXHAUSTION OF MEDIUM. PHASE II RESEARCH WILL EXTEND THESE RESULTS TO THE COMMERCIALLY RELEVANT SITUATIONS OF HIGH CULTURE DENSITIES AND CONTINUOUS CULTIVATION.

Principal Investigator:

Anton F. Steuer
Principal Investigator
3012610800

Business Contact:

Small Business Information at Submission:

Biotech Research Laboratory
1600 E. Gude Drive Rockville, MD 20850

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No