Infant ventilators should be tested under physiological loadconditions before being used for infant care. testing should also be performed periodically during use to verify that they are functioning as expected and according to criteria established by various standards agencies. there is no tester… More

The work involves the design and testing of new enzyme-based amperometric glucose sensors. Electrical communication between the flavin redox centers of glucose oxidase and an electrode is achieved via a network of donor-acceptor relays chemically bound to a highly flexible, insoluble, high molecular… More

The overall objective is to develop highly stable electrochemical probes for the monitoring of the reduced cofactor nicotinamide adenine dinucleotide (NADH), which is produced in many enzyme-based immunoassays. These sensors can measure NADH concentrations at low applied potentials, where… More

There is presently a great deal of interest in defecting specific genetic mutations or variants thatcould provide information about an individual's predisposition to a wide variety of diseases, predict anindividual's sensitivity to specific chemicals or drugs, or be used as prognostic indicators for… More

This proposal describes the design and testing of new enzyme-based amperometric sensors for the neurochemically important species, choline, acetylcholine and glutamate. In these devices, the electrical communication between the flavin redox centers of an oxidase and an electrode is achieved via a… More

The goals of the Phase I research period are to construct and test new amperometric biosensors for the determination of several serum enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT), which are frequently associated with alcohol-related… More

The objective of this proposal is to develop a lithium ion-selective electrode, primarily for application to the clinical determination of lithium in patients undergoing therapy for manic depression. The lithium electrodes currently available are not sufficiently selective for lithium relative to… More