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Lithium-Selective Electrodes with Polymeric Ionophores

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22456
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
22456
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Bio-tek Instruments, Inc.
Highland Park Box 998 Winooski, VT 05404
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Lithium-Selective Electrodes with Polymeric Ionophores
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

The objective of this proposal is to develop a lithium ion-selective electrode, primarily for application to the clinical determination of lithium in patients undergoing therapy for manic depression. The lithium electrodes currently available are not sufficiently selective for lithium relative to sodium. The selectivity of these electrodes is determined by the metal affinities of organic molecules that function as ion carriers in polymer membranes. Improved lithium ionophores would enable molecules that function as ion carriers in polymer membranes. Improved lithium ionophores would enable automated analysis of whole blood with minimal handling of blood products by the operator. Similar electrodes for calcium, sodium and potassium are already in use in the clinical analyzer market. The major goal of the proposed project is to improve the lithium selectivity of the most promising family of lithium ionophores by covalent attachment of the ionophores to flexible ethylene oxide and siloxane polymers. This covalent attachment of the ionophores to a polymer backbone should help reduce aggregation and improve the lithium/sodium selectivity by preventing the formation of 2:1 complexes of the ionophore and sodium.

Principal Investigator:

Paul D. Hale
8026554040

Business Contact:

Small Business Information at Submission:

Bio-tek Instruments, Inc.
Highland Park Box 998 Winooski, VT 05404

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No