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Improved Glucose Biosensors

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22199
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22199
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Bio-tek Instruments, Inc.
Highland Park Box 998 Winooski, VT 05404
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Improved Glucose Biosensors
Agency: HHS
Contract: N/A
Award Amount: $49,960.00
 

Abstract:

The work involves the design and testing of new enzyme-based amperometric glucose sensors. Electrical communication between the flavin redox centers of glucose oxidase and an electrode is achieved via a network of donor-acceptor relays chemically bound to a highly flexible, insoluble, high molecular weight polymer. Improvements in stability and selectivity will be pursued through the use of protective polymer coatings and novel enzyme immobilization procedures. The optimized sensors should have widespread technological applications in areas such as the clinical laboratory, veterinary health care, the research laboratory, and the food industry. With the use of protective polymer coatings to prevent fouling of the sensor in biological fluids and electron transfer mediators which are covalently attached to an insoluble polymer to prevent their diffusion away from the electrode, the development of a reusable in vitro blood glucose monitor (for self-monitoring by diabetic patients) appears feasible. The polymeric relay systems are also amenable to needle-type probes which could be useful for many research applications.

Principal Investigator:

Paul D. Hale
8026554040

Business Contact:

Small Business Information at Submission:

Bio-tek Instruments, Inc.
Highland Park Winooski, VT 05404

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No