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Biosensors for Neurotransmitter Detection

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22360
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
22360
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Bio-tek Instruments, Inc.
Highland Park Box 998 Winooski, VT 05404
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1994
Title: Biosensors for Neurotransmitter Detection
Agency: HHS
Contract: N/A
Award Amount: $479,242.00
 

Abstract:

This proposal describes the design and testing of new enzyme-based amperometric sensors for the neurochemically important species, choline, acetylcholine and glutamate. In these devices, the electrical communication between the flavin redox centers of an oxidase and an electrode is achieved via a network of donor-acceptor relays chemically bound to a highly flexible polymer. Because the electron transfer mediators are covalently attached to an insoluble polymer and cannot diffuse away from the electrode, these sensors should be suitable for implantation; thus, they would be useful for in vivo neurochemical research. The research plan concerns the development of highly sensitive and selective micro-biosensors which can be used as implantable probes or in combination with conventional microdialysis techniques. The sensors should permit detection of these neurochemicals over much shorter time scales than presently available assays.

Principal Investigator:

Paul D. Hale
8026554040

Business Contact:

Small Business Information at Submission:

Bio-tek Instruments, Inc.
Highland Park Box 998 Winooski, VT 05404

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No