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Surface-Enhanced Detection of Molecular and Biomolecular Species

Award Information

Department of Defense
Air Force
Award ID:
Program Year/Program:
2005 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
17546 Bee Line Hwy JUPITER, FL 33458-6433
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2005
Title: Surface-Enhanced Detection of Molecular and Biomolecular Species
Agency / Branch: DOD / USAF
Contract: FA9550-05-C-0136
Award Amount: $100,000.00


This Phase I STTR will demonstrate the feasibility of near-infrared (near-IR) excited surface-enhanced Raman optical activity (SEROA) as a sensitive new probe of biological molecules and trace chiral materials. The research will use nanoshells as fabricated and optimized at Rice University as a newly developed, tunable, highly-uniform, SERS substrates for chiral molecules and bio-molecules. The feasibility of SEROA using a standard ChiralRAMAN ROA spectrometer from BioTools, Inc. with 532 nm excitation will be determined using commercially available SERS substrates. The project continues with the assembly and testing of a near-IR 785-nm laser version of the ChiralRAMAN spectrometer. The new 785-nm ROA instrument will then be tested in three ways. 1) Its performance as a near-IR excited Raman spectrometer will be compared to the Raman performance of the 532-nm ChiralRAMAN spectrometer. 2) Its performance will next be compared to the near-IR Raman spectrometer currently operating at Rice University for which SERS measurements with tuned nanoshells have been carried out. 3) Finally, its performance as the world's first near-IR ROA spectrometer will be tested with standard liquid samples of chiral terpene molecules. From these comparisons a quantitative prognosis for developing a near-IR SEROA spectrometer using chiral tuned-nanoshells will be established.

Principal Investigator:

Laurence A. Nafie
Distinguished Professor

Business Contact:

Rina K. Dukor
President and CEO
Small Business Information at Submission:

Biotools, Inc.
950 North Rand Rd, Suite 123 Wauconda, IL 60084

EIN/Tax ID: 364350206
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Department of Chemistry, 1-104 CST
Syracuse, NY 13244
Contact: Trish Lowney
Contact Phone: (315) 443-2882
RI Type: Nonprofit college or university