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Surface-Enhanced Detection of Molecular and Biomolecular Species

Award Information

Department of Defense
Air Force
Award ID:
Program Year/Program:
2007 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
17546 Bee Line Hwy JUPITER, FL 33458-6433
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2007
Title: Surface-Enhanced Detection of Molecular and Biomolecular Species
Agency / Branch: DOD / USAF
Contract: FA9550-07-C-0032
Award Amount: $750,000.00


This Phase II STTR project continues the development of two prior successful Phase I STTR projects aimed at developing surface-enhance Raman optical activity (ROA) on near-infrared tuned gold-coated nanoshells for the detection of chiral molecules, biological molecules and higher biological structures and organisms for applications in the areas of biological research, pharmaceutical development and bio-defense technology. The principal Phase I outcomes of this project were 1) the construction of the first ROA spectrometer outside the visible region that has the advantages of low fluorescence and exceptional sensitivity to near-IR tuned gold-coated nanoshells, and 2) the fabrication of both solution and solid films of nanoshells with the chiral molecule S-phenyethylenethiol (S-PET) attached. Phase II research will consist of the optimization of SERS/SEROA sampling to overcome aggregation with time of the nanoshell samples in solution phase and spectral variations associated with changing the location of laser focus on the nanoshell film samples. New chiral nanoshells will be fabricated using a variety of attachment mechanisms for samples of increasing biological significance and complexity. A more compact version of the near-IR SEROA spectrometer will be developed with the added capability of microscope attachment for interrogation of sample variation and uniformity of the SERS/SEROA substrates. Theoretical calculations will support the interpretation of new SEROA spectra.

Principal Investigator:

Naomi Halas
Professor, Rice University

Business Contact:

Rina K. Dukor
president / CEO
Small Business Information at Submission:

950 North Rand Rd, Suite 123, Suite 123 Wauconda, IL 60084

EIN/Tax ID: 364350206
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
PO Box 1892
Houston, TX 77005
Contact: Hann Langberg
Contact Phone: (713) 348-5584
RI Type: Nonprofit college or university