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RAPID BIOSENSOR TEST FOR HEPB CORE ANTIGEN ANTIBODIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7891
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7891
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biotronic Systems Corp.
15225 Shady Grove Rd #306 Rockville, MD 20850
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: RAPID BIOSENSOR TEST FOR HEPB CORE ANTIGEN ANTIBODIES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A RAPID, COST-EFFECTIVE TEST FOR HUMAN ANTIBODIES TO HEPATITIS B CORE ANTIGEN (HEPBCA) WHICH WOULD BE SUITABLE FOR PREDONATION SCREENING OF BLOOD DONORS, AND WOULD UTILIZENOVEL CAPACITIVE AFFINITY SENSOR TECHNOLOGY. THE SPECIFIC AIMS OF THIS RESEARCH ARE: 1) TO EVALUATE METHODS BY WHICH HEPBCA CAN BE IMMOBILIZED ON THE SURFACE OF THE BIOSENSOR, 2) TO EVALUATE A HUMAN SERUM PROTEIN AS A COATING FOR A REFERENCE BIOSENSOR, AND 3) TO DETERMINE THE MAGNITUDE AND SPECIFICITY OF THE CAPACITANCE CHANGES WHEN HEPBCA- AND HUMAN SERUM PROTEIN-COATED BIOSENSORS INTERACT WITH MOUSE MONOCLONAL AND HUMAN ANTIBODIES AGAINST HEPBCA. THIS PROJECT WILL CONTRIBUTE TO TECHNOLOGICAL INNOVATION BY ASSESSING THE APPLICABILITY OF CAPACITIVE AFFINITY SENSOR TECHNOLOGY TO A MAJOR CURRENT PROBLEM FOR BLOOD BANKS: THE HIGH COST OF TESTING FOR ANTIBODIES TO HEPBCA, A SURROGATE TEST FOR NON-A, NON-B HEPATITIS. DEVELOPING A HEPBCA ANTIBODY TEST SUITABLE FOR PREDONATION SCREENING OF DONORS SHOULD HAVE SUBSTANTIAL COMMERCIAL POTENTIAL, BOTH IN THE U.S. AND IN SEVERAL FOREIGN COUNTRIES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Biotronic Systems Corp
15225 Shady Grove Rd Ste 306 Rockville, MD 20850

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No