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Reproductive Toxicology of Boron Analogs of Biomolecules

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
24953
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24953
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BORON BIOLOGICALS, INC.
620 HUTTON ST, STE 104 RALEIGH, NC 27606
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Reproductive Toxicology of Boron Analogs of Biomolecules
Agency: HHS
Contract: 1 R43 HD31393-1,
Award Amount: $73,004.00
 

Abstract:

Boron analogs of biomolecules exhibit considerable therapeutic potential in the areas of cancertreatment, bone disorder (such as osteoporosis), hyperlipidemia and inflammation. Considerable activityhas been demonstrated in cell cultures and rodent models. Most of the agents tested for acute toxicityappear to be safe. Considering, however, the reproductive and endocrine toxicity of boric acid (and itsborate salts), it its important to determine whether boron analogs of biomolecules exhibit similar toxicity.The Phase I studies will focus on synthetic methods development (to produce large quantities ofmaterials for toxicity studies), development of bioassays for determining testicular and endocrine effects,and screening of compounds using the newly developed bioassays. In Phase II studies, compounds willbe tested for endocrine lesions using the rapid endocrine bioassay and to determine their relativeimportance for drug development. This toxicity information, combined with the pharmacological activityalready observed, will then enable us to continue the development of pharmacologically active boroncompounds.

Principal Investigator:

Bernard Spielvogel
9198322044

Business Contact:

Small Business Information at Submission:

Boron Biologicals, Inc.
620 Hutton Street, Suite 104 Raleigh, NC 27606

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No