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Boronated Nucleoside Bases

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22031
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22031
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BORON BIOLOGICALS, INC.
620 HUTTON ST, STE 104 RALEIGH, NC 27606
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Boronated Nucleoside Bases
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

We will design and synthesize novel nucleic acid base derivatives containing cyanoborane group attached to a pyridine-type nitrogen atom of the purine or the pyrimidine cycle. The cyanoboronated bases may be designed to be more membrane soluble than the respective 2'- deoxyribonucleosides of known cytotoxic activities. In living organisms, these base derivatives may be converted to the 5'-nucleotides according to salvage pathways, even in cases when the respective 2'- deoxyribonucleosides are poor substrates for nucleoside kinases. Therefore, the cyanoboronated bases are expected to show better cytotoxic activities than the cyanoboronated 2'-deoxyribonucleosides and are feasible to use as antineoplastic agents. An additional importance is the potential for the compounds to be used in boron neutron capture therapy for the treatment of cancer. A rationale for the general synthetic approach to cyanoboronated nucleic acid bases is presented.

Principal Investigator:

Bernard F. Spielvogel
9198322044

Business Contact:

Small Business Information at Submission:

Boron Biologicals, Inc.
620 Hutton Street, Suite 104 Raleigh, NC 27606

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No