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Selective Silver Staining of DNA Probes

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29454
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29454
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BORON BIOLOGICALS, INC.
620 HUTTON ST, STE 104 RALEIGH, NC 27606
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Selective Silver Staining of DNA Probes
Agency: HHS
Contract: 1 R43 GM52768-01,
Award Amount: $100,000.00
 

Abstract:

The major impediment to the wide implementation of DNA diagnostic methods is their cost. Technologisimplify current DNA diagnostic methods and to make them cost competitive with antibody based assaysdesirable. Our new selective silver staining technology could dramatically enhance the price/performand the speed of many currently available DNA based diagnostic methods. Compared to leading alternatpotential advantages of our proprietary technology are reduced material costs, faster detection proc(eliminating radioisotopes or toxic dyes), greater ease of use for manual systems and greater ease oresults with model compounds clearly show the possibility of selectively staining DNA probes. Phasedetermining feasibility with large probe size DNA fragments in real situations on gels or membranes,limit of detection. Methods will also be investigated to improve the yield of modified nucleotides rof probes. Phase II studies will focus on methods of quantitation, demonstration of feasibly with cldiagnostic methods using selective silver staining.

Principal Investigator:

Bernard Spielvogel
91932

Business Contact:

Small Business Information at Submission:

Boron Biologicals, Inc.
620 Hutton Street, Suite 104 Raleigh, NC 27606

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No