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P-Carboranylalanine Analogs of BPA for NCT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29225
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29225
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BORON BIOLOGICALS, INC.
620 HUTTON ST, STE 104 RALEIGH, NC 27606
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: P-Carboranylalanine Analogs of BPA for NCT
Agency: HHS
Contract: 1 R43 CA67549-01,
Award Amount: $100,000.00
 

Abstract:

Boron Neutron Capture Therapy (BNCT) is a very promising therapy for certain tumors, such as gliomamelanomas. p-Boronophenylalanine (BPA), an analog of phenylalanine, is one of the leading BNCT agentundergoing clinical trials in the U.S. for the treatment of gliomas and melanomas. It has already beJapan for the treatment of melanoma. Although very effective, a major drawback of BPA is the high dorequired to achieve clinically effective concentration of boron- 10 in the tumor. It would be quitenew BPA analogs that retain the physico-chemical and bio-distribution properties of BPA, yet have hiThe Phase I studies are therefore designed to synthesize analogs of BPA with high boron content andfunctional groups. The high boron content will allow the use of smaller quantities of BNCT agents, wfunctional group provides a handle to control the physico-chemical properties to optimize the strucuptake and selectivity. The phase I studies will also evaluate the in vitro cell uptake and biologicPhase II research will focus on further structure optimization and in vivo BNCT efficacy and toxicol

Principal Investigator:

Anup Sood
91932

Business Contact:

Small Business Information at Submission:

Boron Biologicals, Inc.
620 Hutton Street, Suite 104 Raleigh, NC 27606

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No