USA flag logo/image

An Official Website of the United States Government

Polarization Imaging Apparatus for Cell and Tissue Imaging and Diagnostics

Award Information

National Aeronautics and Space Administration
Award ID:
Program Year/Program:
2006 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2006
Title: Polarization Imaging Apparatus for Cell and Tissue Imaging and Diagnostics
Agency: NASA
Contract: NNJ06JE57C
Award Amount: $598,396.00


This work proposes to capitalize on our Phase I success in a novel visible-near infrared Stokes polarization imaging technology based on high performance fast tunable phase retarder and novel algorithms for analyzing and diagnosing biological phantoms and cells. Phase I results have demonstrated the feasibility of this technique in in-vivo analyzing biological phantoms and cells. In this Phase II proposal, Boston Applied Technologies Incorporated, will team up with the Catholic University of America and Georgetown University to further develop this technique and apply it to biological cell analysis. Prototypes Stokes imaging system with real time video will be designed and developed. Computer-aided diagnosis software will be further developed for the imaging system with improved classification accuracy and speed. The Stokes polarization imaging system and its computer-aided diagnosis software will be tested on fresh tissue samples from laboratory animals. The tissues will include normal tissues from multiple organs as well as cancerous tissue from laboratory animals. The Stokes images will be compared to reflectance confocal microscopy images and standard light microscopy images to reveal the polarization fingerprints of biological tissues/cells.

Principal Investigator:

Yingyin K. Zou
Principal Investigator

Business Contact:

Yingyin Zou
Business Official
Small Business Information at Submission:

Boston Applied Technologies, Inc.
6F Gill Street Woburn, MA 01801

EIN/Tax ID: 510414999
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
The Catholic University of America
620 Michigan Avenue, NE
Washington, DC 20061
Contact: John Convey
Contact Phone: (202) 319-5244
RI Type: Nonprofit college or university