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Generation of Peptide-Based Ligands for Chemical and Biological Agent…

Award Information

Agency:
Department of Defense
Branch:
Air Force
Award ID:
82063
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
F071-132-0039
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Caldera Pharmaceuticals, Inc.
278 DP Road Suite D LOS ALAMOS, NM -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Generation of Peptide-Based Ligands for Chemical and Biological Agent Identification
Agency / Branch: DOD / USAF
Contract: FA8650-07-M-5410
Award Amount: $100,000.00
 

Abstract:

Caldera will use its R&D 100 award-winning Reagentless Pharmacoproteomic Measurement (RPM) technology to develop chemical/biological (C/B) agent taggants for incorporation into a portable read-out device. RPM technology was developed at Los Alamos National Laboratory and licensed to Caldera. We propose: (1) to generate selective peptide-based capture agent molecules which form highly specific complexes with C/B agents, thereby eliminating the false positive problems that plague current sensors, (2) to develop the ability to "report" binding events, and (3) to produce a prototype sensor device. RPM offers direct chemical measurement of analyte-ligand binding affinity and analyte-ligand selectivity. Caldera will incorporate reporter functional groups into these ligands, to provide for optical reading of C/B agent presence and concentration. We offer a highly novel approach for the generation of non-antibody, peptide-based capture agents, performed by a team with proven expertise in developing label-free reporter methodologies and C/B sensors. RPM technology is extremely rapid and adaptable, which are both attributes necessary due the ever-changing threat situation.

Principal Investigator:

Eva Birnbaum
CSO
5056612420
eva@cpsci.com

Business Contact:

Benjamin Warner
CEO
5054122345
warner@cpsci.com
Small Business Information at Submission:

CALDERA PHARMACEUTICALS, INC.
3491 Trinity Drive, Suite B Los Alamos, NM 87544

EIN/Tax ID: 200982060
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No