USA flag logo/image

An Official Website of the United States Government

THE GOAL OF THE PROPOSED RESEARCH IS TO PRODUCE EFFECTIVE HUMAN PARATHYROID…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3186
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3186
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THE GOAL OF THE PROPOSED RESEARCH IS TO PRODUCE EFFECTIVE HUMAN PARATHYROID HORMONE (PTH) ANTAGONIST PEPTIDES IN ESCHERICHIA COLI USING STATE-OF-THE-ART RECOMBINANT DNA (RDNA) TECHNOLOGIES.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE GOAL OF THE PROPOSED RESEARCH IS TO PRODUCE EFFECTIVE HUMAN PARATHYROID HORMONE (PTH) ANTAGONIST PEPTIDES IN ESCHERICHIA COLI USING STATE-OF-THE-ART RECOMBINANT DNA (RDNA) TECHNOLOGIES. THE CLINICAL UTILITY OF AN EFFECTIVE ANTAGONIST TO PTH ACTION IN VIVO LIES IN THE TREATMENT OF HYPERCALCEMIC DISORDERS INVOLVING THE OVERPRODUCTION OF PTH AND PTH-LIKE COMPOUNDS. THE PRODUCTION OF PTH ANTAGONIST PEPTIDES IN MICROORGANISMS MAY BE MORE ECONOMICALLY FEASIBLE THAN THE CURRENT COSTLY METHOD OF PRODUCTION USING CHEMICAL SYNTHESIS. MORE IMPORTANTLY, IN CONTRAST TO CONVENTIONAL CHEMICAL SYNTHESIS, A VARIETY OF DIFFERENT ANALOGUES CAN BE READILY AND ECONOMICALLY PRODUCED BY SIMPLY ALTERING THE GENE FOR THE ANTAGONIST PEPTIDE USING STANDARD RDNA METHODOLOGIES. THEREFORE THE PROPOSED PHASE I RESEARCH WILL DETERMINE WHETHER A PTH ANTAGONIST PEPTIDE SIMILAR TO THAT DESCRIBED BY ROSENBLATT AND COLLEAGUES (HORIUCHI, N., HOLICK, M.F., POTTS, J.T. AND ROSENBLATT, M. 1983 SCIENCE 220, 10351055) CAN BE PRODUCED IN SIGNIFICANT QUANTITIES AND EFFICIENTLY PURIFIED FOR E. COLI. THIS WORK IS CRITICAL TO THE PHASE II RESEARCH PLAN WHICH WILL REQUIRE SIGNIFICANT QUANTITIES OF PTH

Principal Investigator:

George phillip vlasuk
PRINCIPAL INVESTIGATOR
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Frontage Road Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No