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HYPERTENSION, RESULTING IN SECONDARY ORGAN DAMAGE AND REDUCED LIFE SPAN, IS ONE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3223
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3223
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: HYPERTENSION, RESULTING IN SECONDARY ORGAN DAMAGE AND REDUCED LIFE SPAN, IS ONE OF THE MOST IMPORTANT PUBLIC HEALTH PROBLEMS IN DEVELOPED COUNTRIES.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

HYPERTENSION, RESULTING IN SECONDARY ORGAN DAMAGE AND REDUCED LIFE SPAN, IS ONE OF THE MOST IMPORTANT PUBLIC HEALTH PROBLEMS IN DEVELOPED COUNTRIES. IT IS A MULTIFACTORIAL DISEASE FOR WHICH ETIOLOGY IS UNKNOWN IN 95% OF CASES. THERE IS CURRENTLY NO PREDICTIVE DIAGNOSIS FOR THIS DISEASE. THE LONG-TERM OBJECTIVE OF THE PROJECT DESCRIBED IN THIS PROPOSAL IS THE DEVELOPMENT OF A DIAGNOSTIC TEST FOR THE DETECTION OF AN INDIVIDUAL'S SUSCEPTIBILITY TO HYPERTENSION. THE METHOD WILL BE BASED ON THE ANALYSIS OF RESTRICTION FRAGMENT-LENGTH POLYMORPHISMS WHICH ARE SCATTERED THROUGHOUT THE HUMAN GENOME AND WHICH MAY CORRELATE WITH RISK FACTORS INVOLVED IN THE ONSET OF THE DISEASE. RENIN AND ATRIAL NATRIURETIC FACTOR PLAY A KEY ROLE IN THE REGULATION OF BLOOD PRESSURE. THEREFORE, WE PROPOSE IN PHASE I TO FIND GENETIC MARKERS AT THE RENIN AND ATRIAL NATRIURETIC FACTOR GENE LEVELS AND TO CORRELATE THE PRESENCE OF THESE MARKERS WITH SPECIFIC TYPES OF HYPERTENSION. PHASE II EFFORT WILL EXTEND STUDIES TO THESE AND OTHER GENES INVOLVED IN THE DEVELOPMENT OF HYPERTENSION. LARGER PATIENT POPULATIONS WILL ALSO BE CONSIDERED. THE TEST THAT WE WILL DEVELOP WILL BE COMMERCIALIZED IN THE FORM OF A DIAGNOSTIC KIT TO DETECT INDIVIDUALS AT RISK FOR HYPERTENSION SO THAT TRUE PREVENTION CAN BE PRACTICED.

Principal Investigator:

Philippe m. frossard
PRINCIPAL INVESTIGATOR
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Frontage Rd. Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No