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THE RECENT DISCOVERY OF ATRIAL NATRIURETIC FACTOR (ANF) PEPTIDES IN MAMMALIAN…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3225
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3225
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THE RECENT DISCOVERY OF ATRIAL NATRIURETIC FACTOR (ANF) PEPTIDES IN MAMMALIAN ATRIA THAT HAVE POTENT NATRIURETIC, DIURETIC AND VASORELAXANT ACTIVITY HAS IMPLICATED THESE SUBSTANCES IN THE CONTROL OF FLUID VOLUME AND BLOOD PRESSURE.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE RECENT DISCOVERY OF ATRIAL NATRIURETIC FACTOR (ANF) PEPTIDES IN MAMMALIAN ATRIA THAT HAVE POTENT NATRIURETIC, DIURETIC AND VASORELAXANT ACTIVITY HAS IMPLICATED THESE SUBSTANCES IN THE CONTROL OF FLUID VOLUME AND BLOOD PRESSURE. THE PROPOSED RESEARCH WILL PROVIDE RELEVANT STRUCTURE-ACTIVITY DATA FOR THESE PEPTIDES WITH THE SHORT-TERM GOAL OF PREPARING ANALOGS THAT CONTAIN THE MINIMALLY REQUIRED AMINO ACID SEQUENCE FOR SIGNIFICANT EXPRESSION OF BIOLOGICAL ACTIVITY. FROM THIS STUDY WE WILL SEE IF ANF ANALOGS FORM A BASIS FOR RATIONAL NEW THERAPEUTIC APPROACHES FOR TREATMENT OF CARDIOVASCULAR DISEASE. THE PROPOSED STUDY WILL ESTABLISH A STARTING POINT FOR FUTURE ANALOG DESIGN WITH THE ULTIMATE GOAL OF OBTAINING ORALLY ACTIVE, METABOLICALLY STABLE ANF AGONISTS.

Principal Investigator:

Robert m. scarborough
PRINCIPAL INVESTIGATOR
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Frontage Rd. Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No