ACCELERATED WOUND HEALING WITH FIBROBLAST GROWTH FACTOR

Award Information

Agency: Department of Health and Human Services

Branch: N/A

Contract: N/A

Agency Tracking Number: 4931

Amount: $500,000.00

Phase: Phase II

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1988

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

California Biotechnology, Inc.

2450 Bayshore Frontage Rd

Mountain View, CA 94043

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: John C Fiddes
Title: Principal Investigator
Phone: (415) 966-1550

Business Contact

Phone: () -

Research Institution

N/A

Abstract

BASIC AND ACIDIC FIBROBLAST GROWTH FACTORS (FGF) ARE TWO PRIMARY MITOGENS FOR CAPILLARY ENDOTHELIAL CELLS. BOVINE BASIC FGF, ISOLATED FROM PITUITARIES, WILL BE USED IN RAT WOUND HEALING MODELS TO DETERMINE WHETHER THIS FACTOR CAN ACCELERATE THE RATE OF WOUND HEALING THROUGH PROMOTING ANGIOGENESIS. THIS IS THE FIRST STEP TOWARDS DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF BURN AND OTHERTRAUMA VICTIMS WHO HAVE POORLY HEALING WOUNDS. TO OBTAIN A SOURCE OF THE HUMAN FGFS, FOR FURTHER ANIMAL TESTS AND FOR EVENTUAL CLINICAL TRIALS, THE DNA SEQUENCES ENCODING BOTH BASIC AND ACIDIC FGF WILL BE CLONED. THIS WILL ALLOW THE FUTURE DEVELOPMENT OF RECOMBINANT DNA EXPRESSION SYSTEMS FORHUMAN PROTEINS.

* Information listed above is at the time of submission. *

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ACCELERATED WOUND HEALING WITH FIBROBLAST GROWTH FACTOR