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ANGIOGENESIS WITH ANTAGONIST AND AGONIST ANALOGS OF BASIC FGF

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7314
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
7314
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1989
Title: ANGIOGENESIS WITH ANTAGONIST AND AGONIST ANALOGS OF BASIC FGF
Agency: HHS
Contract: N/A
Award Amount: $494,000.00
 

Abstract:

BASIC FIBROBLAST GROWTH FACTOR (BFGF) IS A POTENT MITOGEN AND ANGIOGENESIS-PROMOTING FACTOR. ANALOGS OF BFGF WILL BE SYNTHESIZED BY IN VITRO MUTAGENESIS OF A DNA FRAGMENT CODINGFOR HUMAN BFGF. THE MUTATED BFGF-CODING DNA FRAGMENT WILL BE ENGINEERED INTO A BACTERIAL EXPRESSION VECTOR AND TRANSFECTED INTO BACTERIA. THE BFGF ANALOGS PRODUCED BY THEBACTERIA WILL BE PURIFIED BY HEPARIN-SEPHAROSE CHROMATOGRAPHY AND TESTED FOR AGONIST AND ANTAGONIST ACTIVITY TO BOVINE PITUITARY BFGF USING TWO DIFFERENT CELL ASSAYS AND A BFGF-RECEPTOR-BINDING ASSAY. THIS IS A FIRST STEP TOWARD DEVELOPING POTENTIAL THERAPEUTICS FOR REGULATINGANGIOGENESIS BASED ON THE STRUCTURE OF BFGF.

Principal Investigator:

Andrew A Protter Phd
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc.
2450 Bayshore Parkway Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No