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EXPRESSION VECTORS FOR SECRETED HUMAN ESTROGEN RECEPTOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7189
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7189
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: EXPRESSION VECTORS FOR SECRETED HUMAN ESTROGEN RECEPTOR
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG-TERM GOAL OF THE RESEARCH IS TO OBTAIN A CHINESE HAMSTER OVARY CELL LINE CAPABLE OF PRODUCING HUMAN ESTROGEN RECEPTOR AS A SIGNIFICANT AMOUNT OF ITS SECRETED PROTEIN. PURIFIED RECEPTOR PROTEIN MAY THEN BE USED (1) TO OBTAIN X-RAY CRYSTALLOGRAPHIC DATA ON THE STRUCTURE OF THE RECEPTOR TO AID IN RATIONAL ANTI-ESTROGEN DRUG DESIGN, AND (2) TO ACT AS A RESEARCH REAGENT FOR THE DEVELOPMENT OF ESTROGEN ANTAGONISTS FOR TREATMENT OF ESTROGEN RECEPTOR TUMORS. THE SPECIFIC AIM OF THE PROPOSAL IS THE PRODUCTION OF A MAMMALIAN CELL EXPRESSION VECTOR CAPABLE OF ENCODING A SECRETED ESTROGEN RECEPTOR AND THE PRODUCTION OF CHO CELL TRANSFECTANT POOLS USING THIS VECTOR. A PRIMARY ACCOMPLISHMENT WILL BE THE INVENTION OF EXPRESSION VECTORS ALLOWING FOR THE RAPID CONSTRUCTION AND IN VITRO ANALYSIS OF ANY NOVEL SECRETORY PROTEIN.

Principal Investigator:

Phyllis a ponte phd
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Frontage Road Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No