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POTENTIAL BIOCHEMICAL DIAGNOSTIC FOR ALZHEIMER'S DISEASE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7847
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7847
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: POTENTIAL BIOCHEMICAL DIAGNOSTIC FOR ALZHEIMER'S DISEASE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

ALZHEIMER'S DISEASE IS A GROWING MEDICAL PROBLEM AFFLICTING 5% OF THE OVER-65 POPULATION IN THE US. DESPITE ITS PREVALENCE, NEITHER POSITIVE DIAGNOSES NOR EFFICACIOUS TREATMENT EXIST. DEFINITIVE DIAGNOSIS IS MADE ON AUTOPSY USING THE HISTOPATHOLOGICAL HALLMARKS OF THE DISEASE - FIBRILLAR AMYLOID PROTEIN WHICH IS DEPOSITED EXTRACELLULARLY AS PLAQUE CORES AND AS CEREBROVASCULATURE AMYLOID. THESE STRUCTURES OCCUR AT APPROXIMATELY 1000-GREATER FREQUENCY THAN IN A NORMAL AGED BRAIN. THE MAJOR CORE PROTEIN OF AMYLOID FIBRILLAR HAS BEEN PURIFIED AND RECENTLY THE CDNA CLONED. THE AIM OF PHASE I IS TO DEVELOP NUCLEIC ACID AND ANTIBODY REAGENTS TO THE CORE PROTEIN WHICH CAN BE UTILIZED TO BUILD A BIOCHEMICAL DIAGNOSTIC FOR ALZHEIMER'S DISEASE. USING THE CDNA SEQUENCE, CORE PROTEIN-SPECIFIC ANTIBODIES WILL BE GENERATEDEITHER FROM SYNTHETIC PEPTIDES OR FROM PROTEINS EXPRESSED BY RECOMBINANT METHODS. IN PHASE II SERA WILL BE SCREENED WITH THE ANTIBODIES AND THE NUCLEIC ACID PROBES TO ASSESS QUALITATIVE AND/OR QUANTITATIVE DIFFERENCES REFLECTING THE DISEASE STATE. SUCH DIFFERENCES WOULD THEN BE DEVELOPED INTO A POSITIVE DIAGNOSTIC FOR ALZHEIMER'S DISEASE.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Frontage Rd Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No