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AN IN VITRO SCREEN FOR ATYPICAL BETA-ADRENERGIC AGONISTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13801
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13801
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: AN IN VITRO SCREEN FOR ATYPICAL BETA-ADRENERGIC AGONISTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE ULTIMATE GOAL OF THIS RESEARCH IS TO DEVELOP A THERAPY FOR OBESITY BASED UPON THE IDENTIFICATION OF NOVEL BETA-ADRENERGIC AGONISTS THAT ARE SELECTIVE STIMULATORS OF THERMOGENESIS IN HUMANS. ATYPICAL (NON-BETA1, BETA2) BETA-ADRENERGIC RECEPTORS (BETA-ARS) ARE THOUGHT TO MEDIATE SYMPATHETIC NERVOUS SYSTEM STIMULATION OF THERMOGENESIS. ATYPICAL BETA- AGONISTS HAVE BEEN SHOWN TO STIMULATE THERMOGENESIS AND PROMOTE WEIGHT LOSS IN ANIMAL MODELS AND IN HUMAN CLINICAL TRIALS, BUT DESPITE THEIR RELATIVE SELECTIVITY, INTERACTIONS WITH BETA1-AR AND BETA2-AR PRODUCE SIDE EFFECTS. IMPROVEMENTS IN AGONIST SELECTIVITY FOR STIMULATION OF THERMOGENESIS WOULD LEAD TO USEFUL THERAPEUTICS. THE SPECIFIC AIM OF THE PROPOSED RESEARCH IS TO ESTABLISH A SCREENING SYSTEM FOR SELECTIVE THERMOGENIC BETA-AGONISTS. DURING PHASE I, THE POLYMERASE CHAIN REACTION (PCR) AND MOLECULAR CLONING TECHNIQUES WILL BE EMPLOYED TO IDENTIFY AND ISOLATE GENES FOR ATYPICAL BETA-ARS EXPRESSED IN TISSUESTHAT ARE SITES FOR THERMOGENESIS IN HUMANS. DURING PHASE II, THE GENES FOR ATYPICAL BETA-ARS WILL BE INTRODUCED INTO CHINESE HAMSTER OVARY CELLS TO ESTABLISH A MATRIX OF CELL LINES EXPRESSING FUNCTIONAL ATYPICAL RECEPTORS, WHICH WILL THEN BE USED TO SCREEN POTENTIAL THERMOGENIC AGONISTS.

Principal Investigator:

R Tyler White
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Pkwy Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No