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A NEW ENDOTHELIAL CELL GROWTH FACTOR FOR WOUND HEALING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13926
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13926
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: A NEW ENDOTHELIAL CELL GROWTH FACTOR FOR WOUND HEALING
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

VASCULAR ENDOTHELIAL CELL GROWTH FACTOR (VEGF) IS A POTENT MITOGEN, SECRETED BY BOVINE PITUITARY FOLLICULO-STELLATE CELLS, THAT APPEARS TO BE SPECIFIC FOR VASCULAR ENDOTHELIAL CELLS. THIS SPECIFICITY SUGGESTS THAT VEGF MAY BE AN IDEAL HUMAN THERAPEUTIC AGENT FOR INDICATIONS WHERE RE-ENDOTHELIALIZATION IS DESIRED IN THE ABSENCE OF PROLIFERATION BY OTHER CELL TYPES; FOR EXAMPLE, AFTER BALLOON ANGIOPLASTY (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY) OR IN CONJUNCTION WITH VASCULAR GRAFTING. THE LONG-RANGE GOALS OF THE PROJECT ARE TO ESTABLISH A RECOMBINANT SOURCE FOR HUMAN VEGF, AND TO USE THE RECOMBINANT PROTEIN TO DETERMINE IN ANIMAL MODELS AND (IF INDICATED) HUMAN CLINICAL TRIALS THE EFFICACY OF VEGF FOR INDICATIONS INVOLVING VASCULAR RE-ENDOTHELIALIZATION. THE PHASE I GOALS ARE TO: (1) USE N-TERMINAL PROTEIN SEQUENCE INFORMATION ALREADY OBTAINED TO ISOLATE BOVINE AND HUMAN CLONES FOR THE VEGF CODING REGION; AND (2) USE EXPRESSION OF THE CLONES, AND INACTIVATION EXPERIMENTS USINGANTIPEPTIDE ANTIBODIES, TO DEMONSTRATE THAT THE SEQUENCE OBTAINED INDEED REPRESENTS THE N-TERMINUS OF THE VEGF PROTEIN, AND TO INITIATE RECOMBINANT PRODUCTION.

Principal Investigator:

Judith A Abraham
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc
2450 Bayshore Pkwy Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No