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STRUCTURE AND FUNCTION OF ALZHEIMER'S DISEASE PROTEASE INHIBITOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13579
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
13579
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: STRUCTURE AND FUNCTION OF ALZHEIMER'S DISEASE PROTEASE INHIBITOR
Agency: HHS
Contract: N/A
Award Amount: $496,634.00
 

Abstract:

APPROXIMATELY 5 PERCENT OF THE POPULATION OVER AGE 65 IN THEUNITED STATES SUFFERS FROM ALZHEIMER'S DISEASE (AD). DESPITE ITS PREVALENCE, NO EFFICACIOUS TREATMENTS EXIST. DEFINITIVE DIAGNOSIS IS MADE ON AUTOPSY USING THE HISTOPATHOLOGICAL HALLMARK OF THE DISEASE-AMYLOID DEPOSITIONIN THE BRAIN AND CEREBROVASCULAR SYSTEM. AMYLOID DEPOSITION OCCURS IN AD AT A FREQUENCY 1,000-FOLD GREATER THAN IN A NORMAL AGED BRAIN. AMYLOID IS DERIVED FROM A LARGER PRECURSOR PROTEIN, AN ALTERNATIVE FORM OF WHICH HARBORS A KUNITZ PROTEASE INHIBITOR. BECAUSE AMYLOID IS DERIVED VIA PROTEOLYTIC CLEAVAGE, THE FUNCTION OF THE INHIBITOR DOMAIN MAY HAVE A CRITICAL ROLE IN BOTH THE NORMAL AND PATHOLOGICAL CONDITION. THE AIM OF PHASE I IS TO PRODUCE A RECOMBINANTLY HOMOGENEOUS INHIBITOR SUITABLE FOR THREE-DIMENSIONAL STRUCTURAL ANALYSIS. PHASE II WILL BE AIMED AT RESOLVING THE TERTIARY STRUCTURE OF THE INHIBITOR, IDENTIFYING ITS TARGET PROTEASE, AND DETERMINING ITS FUNCTIONAL ROLE IN THE PROTEOLYTIC PROCESSING OF THE AMYLOID PRECURSOR. STRUCTURALAND FUNCTIONAL KNOWLEDGE MAY PROVIDE A RATIONALE FOR THERAPEUTIC INTERVENTION IN AD.

Principal Investigator:

Barbara Cordell
4159661550

Business Contact:

Small Business Information at Submission:

California Biotechnology Inc.
2450 Bayshore Pkwy Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No