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ISOLATION OF INSULIN RECEPTOR PHOSPHATASES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16535
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16535
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
California Biotechnology, Inc.
2450 Bayshore Parkway Mountain View, CA 94043
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: ISOLATION OF INSULIN RECEPTOR PHOSPHATASES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE ULTIMATE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A NOVEL TREATMENT FOR DIABETES BASED ON THE ENHANCEMENT OF INSULIN ACTION THROUGH THE INHIBITION OF AN INSULIN RECEPTOR-SPECIFIC PHOSPHOTYROSINE PHOSPHATASE (PTPASE). PHOSPHORYLATION OF THE INSULIN RECEPTOR BETA-SUBUNIT, IN RESPONSE TO INSULI BINDING, HAS BEEN CORRELATED WITH ACTIVATION OF THE PLEIOTROPHIC INTRA- CELLULAR INSULIN SIGNAL. MODULATION OF THE PHOSPHORYLATION STATE OF THE INSULIN RECEPTOR COULD AFFECT POST-RECEPTOR SIGNALLING EVENTS. THE SPECIFIC AIMS OF THIS PROJECT ARE TO IDENTIFY AND PURIFY AS INSULIN RECEPTOR PTPASE(S). DURING PHASE I, WE WILL IDENTIFY AND PARTIALLY PURIFY AN INSULIN RECEPTOR-SPECIFIC PTPASE. THE SPECIFICITY OF THE PHOSPHATASE WILL BE EXAMINED COMPARING DEPHOSPHORYLATION OF THE INSULIN RECEPTOR TO OTHER PHOSPHOTYROSINE, PHOSPHOSERINE, AND PHOSPHOTHREONINE-CONTAINING SUBSTRATES. DURING PHASE II, WE WILL CONTINUE PURIFICATION, GENERATE MONOCLONAL ANTIBODIES, AND IDENTIFY THE CDNA ENCODING THE INSULIN RECEPTOR PTPASE ACTIVITY.

Principal Investigator:

Sweet, Laurel J
Principal Investigator
4159661550

Business Contact:

1 r43 dk44046-01
Small Business Information at Submission:

California Biotechnology, Inc
2450 Bayshore Parkway Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No