The purpose of our research program is to develop a helium-cooled absolute radiometer suitable for wide-band measurements of the earth's radiation at an angular resolution two orders of magnitude better than achieved withthe existing erbe radiometers. we have constructed and characterized a… More

Macroscopic electric fields play a central role in the processes of reconnection and particle acceleration that figure prominently in solar-terrestrial physics studies of flares and filament eruptions. detection of these fields and measurment of their magnitude, orientation, spatial distribution,… More

The purpose of our research program is to develop an automated facility for calibration and testing of electro-optic detectors. we have developed a very precise and flexible electro-optic servo system which provides extremely stable and easily computer-controlled light output from a wide range of… More

Recent advances in liquid crystal technology make it possible to construct tunable birefringent filters operatingover the range 3,500-20,000 angstroms, with passbands as narrow as 50 angstroms. the center wave-length of this filter can be selected electronically, in a few milliseconds, with no… More

A liquid crystal image-preserving tunable filter (iptf) for cell microscopy is planned. recent developments in birefringent liquid crystal technology should make it possible to construct an inexpensive, large-aperture tunablefilter that ranges from 350 to 3,000 nm in a few milliseconds with no… More

Frequency-agile Fabry-Perot etalons have been built using the electro-optic actin of nematic and ferro-electric liquid crystals to tune the pass wavelength. Also, techniques exist for constructing liquid crystall elements in 1-D and 2-D arrays. The combination of these technologies would yield… More

Tunable filters developed by us, based on electrically-tuned liquid crystal waveplates, providefluorescence microscopists with fast, continuous and automated selection of emission wavelengthwithout vibration, image shift, or detectable degradation of image quality. They can be used to convertany… More

In our Phase 1 work we were able to replicate and build on recent results at NIST with superconducting transition (SCT) thermometers, which suggested that dramatic improvements may be achieved in detectivity and range of application, of cryogenic electrical substitution radiometers. Cryo-ESR's are… More

Not Available In our Phase 1 work we were able to replicate and build on recent results at NIST with superconducting transition (SCT) thermometers, which suggested that dramatic improvements may be achieved in detectivity and range of application, of cryogenic electrical substitution radiometers.… More

Not Available A multifunction solar array / antenna can be achieved by integrating the radiating elements into the solar array surface. This study contract will define and evaluate designs which combine advanced solar concentrator technology with traditional antenna ar

DESCRIPTION (provided by applicant): We propose to extend our successful development of an agile spectral light source for light microscopy, funded through the NCI-IMAT initiative, into FDA trials. The SpectraLamp(tm) device enables the automated and quantitative analysis of double-immunostained… More

DESCRIPTION (provided by applicant): Phase I We propose to develop an ultra-sensitive real-time polarized light microscope ("Real-Time PolScope") for analyzing the dynamics of the molecular architecture in living cells, in whole organisms and in cell-free model systems through birefringence… More

DESCRIPTION (provided by applicant): Phase I We propose to develop an ultra-sensitive real-time polarized light microscope ("Real-Time PolScope") for analyzing the dynamics of the molecular architecture in living cells, in whole organisms and in cell-free model systems through birefringence… More

DESCRIPTION (provided by applicant): The objective of this Phase II project is to develop a more effective tool for assessing the development potential of human oocytes and to reduce the emotional, health, and financial costs of low IVF success rates, presently approximately 25% per cycle. To… More

DESCRIPTION (provided by applicant): We propose to extend our successful development of an agile spectral light source for light microscopy, funded through the NCI-IMAT initiative, into FDA trials. The SpectraLamp(tm) device enables the automated and quantitative analysis of double-immunostained… More

DESCRIPTION (provided by applicant): This is a Fast-Track proposal to develop a multispectral optical tomography small-animal imaging system for use by the biomedical and pharmaceutical research communities. It will combine the experience CRI has acquired in multispectral, planar small-animal… More

DESCRIPTION (provided by applicant): This is a Fast-Track application to provide reliable, cellularly resolved molecular pathway assessment in cancer biopsies to assist pharmaceutical drug development and provision of patient-specific prognosis and therapy guidance ( personalized medicine ).… More

DESCRIPTION (provided by applicant): Fluorescence-based molecular Imaging in small animals is having a major impact on drug development and disease research. However, a significant challenge to imaging targeted fluorescent markers in vivo remains: unless t he labeled regions are located… More