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Company Information:

Company Name: CAMBRIDGE RESEARCH AND INSTRUMENTATION
City: WOBURN
State: MA
Zip+4: -
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $2,043,879.00 21
SBIR Phase II $12,891,154.00 14

Award List:

A CRYOGENIC ABSOLUTE RADIOMETER FOR EARTH RADIATION SENSING

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: NASA
Principal Investigator: Dr Peter V Foukal , Principal Investigator
Award Amount: $50,000.00

A CRYOGENIC ABSOLUTE RADIOMETER FOR EARTH RADIATION SENSING

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: NASA
Principal Investigator: Dr Peter V Foukal , Principal Investigator
Award Amount: $100,000.00
Abstract:
The purpose of our research program is to develop a helium-cooled absolute radiometer suitable for wide-band measurements of the earth's radiation at an angular resolution two orders of magnitude better than achieved withthe existing erbe radiometers. we have constructed and characterized a… More

MESUREMENT OF MACROSCOPIC ELECTRIC FIELDS IN SOLAR PLASMA STRUCTURES

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Peter v foukal
Award Amount: $50,000.00
Abstract:
Macroscopic electric fields play a central role in the processes of reconnection and particle acceleration that figure prominently in solar-terrestrial physics studies of flares and filament eruptions. detection of these fields and measurment of their magnitude, orientation, spatial distribution,… More

STABILIZED LASERS AS SPECTRORADIOMETRIC STANDARDS FOR UV ELECTRO-OPTIC DETECTORS

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NASA
Principal Investigator: Dr Peter Foukal
Award Amount: $50,000.00

STABILIZED LASERS AS SPECTRORADIOMETRIC STANDARDS FOR UV ELECTRO-OPTIC DETECTORS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: NASA
Principal Investigator: Dr Peter Foukal
Award Amount: $499,970.00
Abstract:
The purpose of our research program is to develop an automated facility for calibration and testing of electro-optic detectors. we have developed a very precise and flexible electro-optic servo system which provides extremely stable and easily computer-controlled light output from a wide range of… More

IMAGE-PRESERVING TUNABLE FILTER FOR MICROSCOPY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

TUNABLE BIREFRINGENT FILTERS USING LIQUID CRYSTAL ELEMENTS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: NSF
Principal Investigator: Peter J Miller , Principal Investigator
Award Amount: $49,846.00

TUNABLE BIREFRINGENT FILTERS USING LIQUID CRYSTAL ELEMENTS

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: NSF
Principal Investigator: Peter J Miller , Principal Investigator
Award Amount: $229,438.00
Abstract:
Recent advances in liquid crystal technology make it possible to construct tunable birefringent filters operatingover the range 3,500-20,000 angstroms, with passbands as narrow as 50 angstroms. the center wave-length of this filter can be selected electronically, in a few milliseconds, with no… More

IMAGE-PRESERVING TUNABLE FILTER FOR MICROSCOPY

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $500,000.00
Abstract:
A liquid crystal image-preserving tunable filter (iptf) for cell microscopy is planned. recent developments in birefringent liquid crystal technology should make it possible to construct an inexpensive, large-aperture tunablefilter that ranges from 350 to 3,000 nm in a few milliseconds with no… More

FABRICATION OF A VERSATILE HOLOGRAPHIC OPTICAL ELEMENT FOR HIGH RESOLUTION SPECTROSCOPY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: NASA
Principal Investigator: P. Miller
Award Amount: $50,000.00

Electrically Tunable Fabry-Perot Spectral Filter

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Peter Miller
Award Amount: $50,852.00
Abstract:
Frequency-agile Fabry-Perot etalons have been built using the electro-optic actin of nematic and ferro-electric liquid crystals to tune the pass wavelength. Also, techniques exist for constructing liquid crystall elements in 1-D and 2-D arrays. The combination of these technologies would yield… More

FABRICATION OF A VERSATILE HOLOGRAPHIC OPTICAL ELEMENT FOR HIGH RESOLUTION SPECTROSCOPY

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: NASA
Principal Investigator: P. Miller
Award Amount: $486,282.00

High-Efficiency Tunable Fluorescence Emission Filter

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clifford Hoyt
Award Amount: $74,654.00

High-Efficiency Tunable Fluorescence Emission Filter

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clifford Hoyt
Award Amount: $686,507.00
Abstract:
Tunable filters developed by us, based on electrically-tuned liquid crystal waveplates, providefluorescence microscopists with fast, continuous and automated selection of emission wavelengthwithout vibration, image shift, or detectable degradation of image quality. They can be used to convertany… More

SBIR Phase I: A Bolometric Imager for Solar Irradiance Studies

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: NSF
Principal Investigator: Peter Foukal
Award Amount: $71,945.00

SBIR Phase I: High Definition Raman Imaging Microscope

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: NSF
Principal Investigator: Peter Miller
Award Amount: $65,940.00

SBIR Phase I: High Definition Raman Imaging Microscope

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: NSF
Principal Investigator: Peter Miller
Award Amount: $296,753.00

Advanced Absolute Radiometers Using Superconducting Transition Thermometers

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: DOC
Principal Investigator:
Award Amount: $75,000.00
Abstract:
In our Phase 1 work we were able to replicate and build on recent results at NIST with superconducting transition (SCT) thermometers, which suggested that dramatic improvements may be achieved in detectivity and range of application, of cryogenic electrical substitution radiometers. Cryo-ESR's are… More

CCD-BASED FLUORESCENCE POLARIZATION ASSAY PLATE READER

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Hoyt, Clifford C
Award Amount: $99,946.00

Advanced Absolute Radiometers Using Superconducting Transition Thermometers

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: DOC
Principal Investigator:
Award Amount: $299,964.00
Abstract:
Not Available In our Phase 1 work we were able to replicate and build on recent results at NIST with superconducting transition (SCT) thermometers, which suggested that dramatic improvements may be achieved in detectivity and range of application, of cryogenic electrical substitution radiometers.… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clifford C. Hoyt
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clifford C. Hoyt
Award Amount: $415,059.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clifford C. Hoyt
Award Amount: $99,989.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $237,109.00
Abstract:
Not Available A multifunction solar array / antenna can be achieved by integrating the radiating elements into the solar array surface. This study contract will define and evaluate designs which combine advanced solar concentrator technology with traditional antenna ar

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $175,759.00

Spectral imaging for automated malignant blast counting

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $175,759.00
Abstract:
DESCRIPTION (provided by applicant): We propose to extend our successful development of an agile spectral light source for light microscopy, funded through the NCI-IMAT initiative, into FDA trials. The SpectraLamp(tm) device enables the automated and quantitative analysis of double-immunostained… More

Real-time PolScope microscope for live-cell imaging

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $207,516.00
Abstract:
DESCRIPTION (provided by applicant): Phase I We propose to develop an ultra-sensitive real-time polarized light microscope ("Real-Time PolScope") for analyzing the dynamics of the molecular architecture in living cells, in whole organisms and in cell-free model systems through birefringence… More

Real-time PolScope microscope for live-cell imaging

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $2,425,419.00
Abstract:
DESCRIPTION (provided by applicant): Phase I We propose to develop an ultra-sensitive real-time polarized light microscope ("Real-Time PolScope") for analyzing the dynamics of the molecular architecture in living cells, in whole organisms and in cell-free model systems through birefringence… More

Morphology-Based Rating of Egg Development Potential

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clifford C. Hoyt
Award Amount: $1,141,776.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this Phase II project is to develop a more effective tool for assessing the development potential of human oocytes and to reduce the emotional, health, and financial costs of low IVF success rates, presently approximately 25% per cycle. To… More

Spectral imaging for automated malignant blast counting

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $3,036,436.00
Abstract:
DESCRIPTION (provided by applicant): We propose to extend our successful development of an agile spectral light source for light microscopy, funded through the NCI-IMAT initiative, into FDA trials. The SpectraLamp(tm) device enables the automated and quantitative analysis of double-immunostained… More

Spectrally resolved tomographic small-animal fluorescence imager

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $189,993.00
Abstract:
DESCRIPTION (provided by applicant): This is a Fast-Track proposal to develop a multispectral optical tomography small-animal imaging system for use by the biomedical and pharmaceutical research communities. It will combine the experience CRI has acquired in multispectral, planar small-animal… More

Cellularly resolved molecular pathway assessment in biopsies via spectral imaging

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $227,868.00
Abstract:
DESCRIPTION (provided by applicant): This is a Fast-Track application to provide reliable, cellularly resolved molecular pathway assessment in cancer biopsies to assist pharmaceutical drug development and provision of patient-specific prognosis and therapy guidance ( personalized medicine ).… More

In-vivo optical molecular imaging with Dynamic Contrast Enhancement (DyCE)

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $167,462.00
Abstract:
DESCRIPTION (provided by applicant): Fluorescence-based molecular Imaging in small animals is having a major impact on drug development and disease research. However, a significant challenge to imaging targeted fluorescent markers in vivo remains: unless t he labeled regions are located… More

Cellularly resolved molecular pathway assessment in biopsies via spectral imaging

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard M. Levenson
Award Amount: $2,597,791.00