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FISH ASSAY FOR THE DETECTION OF T (14;18) (Q32;21)

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
55600
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
2R44CA084838-02
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CANCER GENETICS, INC.
201Route 17 North Rutherford, NJ -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2001
Title: FISH ASSAY FOR THE DETECTION OF T (14;18) (Q32;21)
Agency: HHS
Contract: N/A
Award Amount: $417,956.00
 

Abstract:

DESCRIPTION (applicant's abstract): Approximately 60 percent of B-cell lymphomas are characterized by the presence of the t(14;18) (q32;q21) chromosomal translocation. Diagnosis and post-treatment follow-up are currently performed by karyotype, Southern blotting, or PCR, which have problems with specificity and sensitivity. Fluorescence in situ hybridization (FISH) addresses these limitations; however, no clinically tested FISH probes are available for detecting the t(14; 18) translocation. Phase I research developed novel probes for interphase FISH analysis of the t(14; 18) translocation. Using both normal and tumor samples, high sensitivity and specificity of the probes were observed. Using tumor specimens from multiple tissue types, Phase II research will validate use of the probes for diagnosis. Phase II research will also validate their use for monitoring minimal residual disease. In Phase II research, the probes will also be optimized to reduce background hybridization signal. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Principal Investigator:

Ramana V. Tantravahi

Business Contact:


6175762155
ED@CANCERGENETICS.COM
Small Business Information at Submission:

CANCER GENETICS
100 INMAN ST, STE 100 CAMBRIDGE, MA 02139

EIN/Tax ID: 043462475
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No