USA flag logo/image

An Official Website of the United States Government

FISH Assay for Acute Myeloid Leukemia

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
53860
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43CA091532-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CANCER GENETICS, INC.
201Route 17 North Rutherford, NJ -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: FISH Assay for Acute Myeloid Leukemia
Agency: HHS
Contract: N/A
Award Amount: $226,508.00
 

Abstract:

DESCRIPTION (Applicant's abstract): The goal of this research is to develop two fluorescence in situ hybridization (FISH) assays for detecting the t(8;21)(q22;q22) and inv(16)(p13q22) and related t(16;16)(p13;q22) translocations found in two different subsets of acute myeloid leukemia (AML), M2 and M4Eo, respectively. These cancers are traditionally treated by chemotherapy; however, many patients relapse and become refractory to treatment. Diagnosis and post treatment follow-up are currently performed by karyotype, Southern blotting or PCR. These methods, however, have limitations in specificity and/or sensitivity. A precise, reliable and simple method for detecting cancer cells, especially in post-treatment specimens, is needed. FISH is an improvement over current methods used for detecting translocations; however, no clinically tested probes are available for detecting AML. This SBIR proposal aims to develop novel, sensitive and specific FISH assays that will unambiguously detect translocation carrying nuclei in diagnostic and follow up patient samples. PROPOSED COMMERCIAL APPLICATION: The proposed research will provide highly specific and sensitive FISH assays for detecting chromosomal translocations present in Acute Myeloid Leukemia (AML) for use in cancer cytogenetic reference laboratories.

Principal Investigator:

Nallasivam Palanisamy

Business Contact:


6175762155
ED@CANCERGENETICS.COM
Small Business Information at Submission:

CANCER GENETICS
100 INMAN ST, STE 100 CAMBRIDGE, MA 02139

EIN/Tax ID: 043462475
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No