Approximately 5% of the u.s. population have disfiguring birthmarks. recently, lasers have been used to heat and destroy nevus flammeus, a common congenital hemangioma, mostoften called port wine stain (pws). not all pws birthmarks respond to treatment with the commonly used argon-ion laser.older… More

Calculi, or stones, in the urinary tract is a recurring problem, affecting nearly 800,000 in the u.s. annually. incisions to remove urinary calculi are highly traumatic, creating tissue damage, pain, and postoperative discomfort. recent advances in technology reduce trauma by minimizing the need for… More

A program to develop lasers suitable for irradiating externally supplied chromophores (dyes) in tissue using selective photothermolysis (sp) is proposed. sp allows precise target specificity in vivo by color selectivity, and spatial selectivity does not depend on focusing but instead depends on time… More

Biliary stone disease affects over 16 million people in the united states. approximately 1 million new cases of cholelthiasis develop each year, and surgical intervention was required in 554,000 procedures in 1984, a 3% increase from 1983. the average length of hospitalization for these patients is… More

Heterodyne holographic interferometry and time-average holography with a frequency shifted beam have been proposed for use in the measurement and visualization of internal transonic flows. a long pulse flashlamp excited dye laser has been shown to produce over 50 millijoules per pulse for over 50… More

Cardiovascular disease is the leading cause of deaths in theunited states, claiming nearly twice as many lives as cancer. laser angioplasty has immense appeal, but a reliable, predictable system has not yet been developed. researchers have conducted preliminary studies to demonstra-te preferential… More

Candela laser corporation and ucla tissue typing laboratory propose to devlop a group of dye tagged monoclonal antibodies and a laser to target these dyes, for the pereferential destruction of human t cells from a mixture oft and b cells and also acinar cells in the present of slit cells. the… More

Vitreoretinal disease is a major cause of blindness. current surgical vitrectomy utilizes mechanical cutting devices. however, mechanical removal of the vitreous may becomplicated by insufficient tissue cutting and/or inadvertent traction on the retina, resulting in retinal tears, detachment, and… More

Candela laser corporation will develop an integrated laser/light delivery system that will provide a surgeon witha tool that can remove small, precise amounts of bone, yet can be employed to cut or shape bone on a large scale. the system and design will strictly minimize any damage to nearby… More

Candela laser corporation together with the center for sightof georgetown university will develop a practical tandem scanning confocal microscope system for confocal imaging of the eye by making a number of improvements to an existing prototype system. specifically, it is planned to: (1) improve the… More

Glaucoma is a leading cause of irreversible blindness in theunited states. filtration surgery is the procedure of choice when medical therapy or laser trabeculoplasty fail tocontrol the intraocular pressure. in this grant application, a non-invasive laser treatment is proposed as an alternative to… More

Age-related macular degeneration (amd) is one of the leading causes of blindness in the united states and the developed world. choroidal neovascularization is the most frequent cause of severe visual loss in patients with amd. infrared fundus videoangiography using indocyanine green dyecan provide… More

Cutaneous pigmented lesions are extremely common in dermatology. although the majority of these lesions are benign, the possibility of malignant transformation in addition to cosmetic considerations have frequently necessitated their therapeutic removal. the laser could be appropriately adapted to… More

The use of large ground based adaptive optics telescopes holds the potential to revolutionize astronomical observation at visible wavelengths. in order to make such systems practical, bright sources (guide stars) must be available over all regions of the sky. such stars can be artificially produced… More

This project addresses the development of fiber optic chemical sensors (focs) as new instrumentation for the in-situ detection and monitoring of specific classes of chemical compounds. in particular, a new method is proposedfor the determination of volatile gem-polyhalogenated hydrocarbons (gpchc)… More

Candela laser corporation and albert einstein medical center will develop and evaluate a pulsed laser system for endodontic therapy based on specific laser target/tissue interaction. employing laser energy delivered to teeth via a flexible fiberoptic, the system will remove diseased pulp and dentin,… More

Candela laser corporation plans to develop a diode laser system for the controlled interstitial illumination of tumors. the apparatus will be designed to utilize the combined effects of hyperthermia and other therapies to treat certain human malignancies. prototype cylindrical tip interstitial… More

This project will develop a clinically useful pulsed laser system to produce highly selective damage to pain-sensitive neurons within the dorsal root (sensory) ganglia. the technology would allow a minimally invasive therapy for intractable pain syndromes associated with malignancy, peripheral… More

Approximately 200,000 patients per year in the united statesundergo the surgical removal of lumbar disks. candela lasercorporation plans to develop a laser-based method for percutaneous decompression of herniated lumbar disks. a pulsed holmium:yag laser with a fiberoptic delivery system will be used… More

Candela laser corporation is proposing the development of anaffordable optical tweezers microscope system based on coupling a diode laser beam to an inverted microscope, in order to satisfy a market need among research workers in biotechnology and thereby stimulate advances in cellular biology. the… More

Choroidal neovascularization is the leading cause of new blindness in the u. s.. conventional treatment of neovascularization involves closure of leaking new vessels by thermal coagulation with argon, krypton, or dye lasers. this treatment causes undesirable thermal damage to the neural retinal.… More

Laser resonance ionization mass spectrometry (lrims) is a powerful analytical tool that permits the detection of ultratrace elements and isotopes in biological systems. this performance is achieved by combining the elemental selectivity of laser resonance ionization with the mass spectrometry. in… More

We will develop a pulsed (non-laser) light source capable of effecting significant curing in one second or less in light cured dental composite resins. the filtered source will be effectively coupled into a light guide delivery system. the depth of cure in a variety of composite resins will be… More

Candela laser corporation, in collaboration with scientists at the university of chicago, seeks to develop a diagnostic instrument to measure the plasma lipoprotein distribution samples after their separation by density gradient ultracentrifugation. the lipoprotein class is identified by location in… More

We will develop a new glaucoma surgery in which laser energy is used to remove trabecular tissue atraumatically. both nd:yag laser trabeculopuncture and conventional trabeculotomy have been used to treat open-angle glaucoma, but these techniques cause mechanical damage to the trabecular meshwork,… More

A new instrument for high-speed flow visualization will be developed and demonstrated. The system will be based on a high repitition rate pulsed Ti:Sapphire laser and high imaging rate camera. Laser technology, to be developed here, allows the laser to be pulsed at rates of 100-300 kHz for a… More

We will develop a cw holmium laser stereotactic endoscopic neurosurgical treatment of hydrocephalus. Hydrocephalus is currently managed by the use of valved shunts to drain cerebrospinal fluid from obstructed ventricles. At present, shunt revision is by far the most common neurosurgical reoperation… More

Candela Laser Corporation, in cooperation with The Johns Hopkins University, will develop a new procedure for treatment and closure of choroidal vessels and neovascular membranes with reduced damage to the retina and better preservation of vision. Choroidal neovascularization is the most frequent… More

The investigators will study the efficacy of long pulsed laser treatment for psoriasis. Psoriasis iwhich is often chronic in nature. Current treatment modalities do not result in a cure of this chroninvestigators wish to develop a safe and efficacious dye laser for psoriasis. The laser radiation… More

Analysis of the characteristic interaction time for laser tissue irradiation suggests that picosecopulses will operate in a temporal regime where photomechanical effects are dominant. At least in thethis mechanism is expected to lead to an improved treatment. To access this new laser treatment… More

We will develop a cost-effective, a traumatic pulsed dye laser treatment for patients withrecurrent respiratory papillomatosis (RRP). RRP is caused by the human papillomavirus (HPV), and ischaracterized by recurrent, nonmalignant, proliferative lesions of the larynx. Patients with RRP… More

DESCRIPTION (provided by applicant): Candela Corporation proposes to develop a laser system for a non-ablative treatment of Acne and related scars. The treatment is based on producing a sub-surface zone of laser-induced thermal injury within the dermis while preserving the epidermis. A laser… More

DESCRIPTION (provided by applicant): The objective of the proposed study is to develop a endovascular diode-laser based technique at a new wavelength for photothermal coagulation and destruction of the greater saphenous vein (GSV) for treatment of varicose veins. Varicose veins are a significant… More