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DYE-ENHANCED LASER HEMOSTASIS AND TUMOR CELL KILLING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1448
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
1448
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CANDELA CORPORATION
530 BOSTON POST ROAD WAYLAND, MA 01778
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: DYE-ENHANCED LASER HEMOSTASIS AND TUMOR CELL KILLING
Agency: HHS
Contract: N/A
Award Amount: $476,000.00
 

Abstract:

A PROGRAM TO DEVELOP LASERS SUITABLE FOR IRRADIATING EXTERNALLY SUPPLIED CHROMOPHORES (DYES) IN TISSUE USING SELECTIVE PHOTOTHERMOLYSIS (SP) IS PROPOSED. SP ALLOWS PRECISE TARGET SPECIFICITY IN VIVO BY COLOR SELECTIVITY, AND SPATIAL SELECTIVITY DOES NOT DEPEND ON FOCUSING BUT INSTEAD DEPENDS ON TIME RESOLUTION. LARGE TISSUE VOLUMES CAN BE TREATED SIMULTANEOUSLY AND NON-TARGET TISSUE SPARED. THE LASERS TO BE DEVELOPED WILL BE COMPATIBLE WITH EXISTING FDA APPROVED STERILE DYES. STUDIES WILL BE CONDUCTED ON ANIMALS FOR THE TREATMENT OF SENILE MACULAR DEGENERATION (SMD), HEMOSTASIS OF GASTROINTESTINAL BLEEDING, AND TUMOR CELL KILLING BY THE IRRADIATION OF DYES CONJUGATED TO MONOCLONAL ANTIBODIES. THE LASERS WILL EMIT IN THE NEAR INFRARED AND WILL HAVE PULSE DURATIONS CORRESPONDING TO TARGET SIZE--SUBMICROSECOND FOR CELLS AND MILLISECONDS FOR VESSELS. THE EMPHASIS WILL BE ON THE TREATMENT OF SMD, THE LEADING CAUSE OF LEGAL BLINDNESS IN THE UNITED STATES. MOST OF THE EYES WITH SMD GO INTO BLINDNESS BECAUSE OF CHOROIDAL NEOVASCULARIZATION. SP PROMISES TO BE SUPERIOR TO EXISTING PHOTOCOAGULATION TECHNIQUES FOR TREATING SMD. IF FEASIBILITY IS PROVEN ON ANIMALS IN PHASE I, THE TREATMENT OF HUMAN SUBJECTS WILL BE THE FOCUS OF A PHASE II GRANT, AND PHASE III WILL RESULT IN A COMMERCIAL PRODUCT.

Principal Investigator:

Hoarce W. Furumoto
Program Director
0

Business Contact:

Small Business Information at Submission:

Candela Corp.
530 Boston Post Rd Wayland, MA 01778

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No