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SBIR TOPIC 245 "PREDICTIVE EFFICACY SCREENING IN CANCER STEM CELLS USING…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94139
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
N43CO0800024
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
STEMINA BIOMARKER DISCOVERY, INC.
504 S. Rosa Road MADISON, WI 53719-1256
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: SBIR TOPIC 245 "PREDICTIVE EFFICACY SCREENING IN CANCER STEM CELLS USING METABOLO
Agency: HHS
Contract: N43CO0800024
Award Amount: $149,528.00
 

Abstract:

Cancer stem cells (CSCs) are a critical tumor subpopulation that may cause local recurrences that plague patients with advanced solid malignancies, even after maximal therapeutic efforts. CSCs can self-renew, differentiate into multiple lineages, resist ra diation and chemotherapy, and efficiently initiate and propagate tumor formation. These characteristics make the quest for assays to measure drug efficacy on CSCs an urgent focus of drug discovery. We propose to identify potential brain tumor stem cell (BT SC) biomarkers- unique small molecule metabolites secreted only by BTSCs- that indicate therapeutic efficacy in CSCs. We will first determine a preliminary BTSC metabolomic footprint by profiling three BTSC cell lines using high-throughput, sensitive mass spectrometry to detect secreted metabolites. Then we will compare the BTSC metabolomic footprint with the footprints of glioblastoma multiforme tumor cells and neural stem cells to establish BTSC-specific metabolites, the biomarkers. Using targeted metabol ite profiling for these biomarkers, we will assess the efficacy of varioous therapeutic agents against BTSCs in vitro after treatment with standard anti-GBM agents and novel theraputics, and correlate efficacy with differential levels of the monitored BTSC -specific metabolites. If successful, we will later conduct in vivo studies based on the efficacy correlations from these in vitro studies.

Principal Investigator:

Paul West

Business Contact:


bdonley@stemina.com
Small Business Information at Submission:

STEMINA BIOMARKER DISCOVERY, INC.
504 S. Rosa Road MADISON, WI 53719

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No