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Sertoli Cell-Treated Umbilical Cord Blood for Stroke

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66651
Program Year/Program:
2003 / STTR
Agency Tracking Number:
NS046878
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SANERON CCEL THERAPEUTICS, INC.
3802 Spectrum Blvd. TAMPA, FL 33612-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Sertoli Cell-Treated Umbilical Cord Blood for Stroke
Agency: HHS
Contract: 1R41NS046878-01
Award Amount: $133,060.00
 

Abstract:

DESCRIPTION (provided by applicant): With the recent observations that stem-like cells outside the central nervous system (CNS) can differentiate into neurons, it is no longer inconceivable to suggest that stem cells derived from human umbilical cord blood (hUCB) could be used for cellular transplant therapy for neurological disorders, such as stroke. However, the greatest confounds of cell transplant therapy include rejection by the recipient (graft vs. host disease), and viability of the stem cells following cryopreservation. We have shown previously that SCs provide long-term localized immunosuppression and growth enhancement of transplanted cells and tissues. SCs provide a cocktail of trophic and immune protective factors that may be chronically present after transplantation. This Phase I research program proposes a series of well-controlled experiments using cell culture techniques to determine the most efficacious protocol for enhancing viability, neural differentiation, and cryopreservation of SC-treated hUCBs, which will be termed SCT-441, prior to their transplantation in an animal model of stroke. The optimal dose of SCT.441 will also be determined based on behavioral recovery. The success of directing and protecting stem cells obtained from umbilical cord blood into a neural phenotype (i.e. SCT-441) has important implications for the treatment of stroke in humans.

Principal Investigator:

Don D. Cameron
8139749431
DCAMERON@HSC.USF.EDU

Business Contact:

Nicole Kuzmin-nichols
8138666370
nkn@saneron-ccel.com
Small Business Information at Submission:

Saneron Ccel Therapeutics, Inc.
13101 TELECOM DR, STE 105 USF, CENTER FOR ENTREPRENEURSHIP Tampa, FL 33637

EIN/Tax ID: 113285112
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF SOUTH FLORIDA
4202 E FOWLER AVE
TAMPA, FL 33620
RI Type: Nonprofit college or university