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Company Information:

Company Name: CELL AND TISSUE SYSTEMS, INC.
City: NORTH CHARLESTON
State: SC
Zip+4: 29406-
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,973,744.00 19
SBIR Phase II $3,953,597.00 3

Award List:

Pancreas Transporter Development and Validation

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael J. Taylor
Award Amount: $1,005,427.00
Abstract:
DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of donor pancreases for islet isolation and… More

Engineered Cartilage Storage and Transport Solution

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $167,275.00
Abstract:
DESCRIPTION (provided by applicant): The overall objective of this proposal is to define the hypothermic storage conditions and shelf life for tissue engineered cartilage constructs (TECCs) required for commercial manufacturing and distribution. Preliminary studies employing TECCs have demonstrated… More

PRESERVATION OF LIVER SLICES BY VITRIFICATION

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Taylor
Award Amount: $148,069.00
Abstract:
DESCRIPTION (provided by applicant): In-vitro drug testing on precision-cut liver slices (PCLS) provides the most realistic biochemical metabolic profile of in-situ conditions for predicting drug toxicity and metabolism during early stage drug development. An ample supply of cryopreserved human… More

PRESERVATION OF LIVER SPHEROIDS

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Lia H. Campbell
Award Amount: $147,863.00
Abstract:
DESCRIPTION (provided by applicant): Assays are being developed in efforts to reduce the number of animals required for research. In particular, cell based systems that can evaluate a variety of compounds and/or screen single compounds with many cell types would provide the most advantageous… More

New Solutions Islet Recovery Preservation of Pancreas

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Taylor
Award Amount: $161,977.00
Abstract:
DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of donor pancreases for islet isolation and… More

Freeze-Dried, Viable Allogeneic Heart Valves

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $170,764.00
Abstract:
DESCRIPTION (provided by applicant): Allogeneic human heart valves are used in approximately 20% of the tissue heart valve procedures performed annually. Most allogeneic human heart valves (also known as allografts or homografts) are cryopreserved and stored in the vapor phase of liquid nitrogen… More

Commercial Feasibility Assessment of Pancreatic Islet Progenitor Cell Technology

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $151,958.00
Abstract:
DESCRIPTION (provided by applicant): The ability of islet transplantation to reproducibly reverse diabetes for extended periods has been demonstrated in recent clinical studies. However the need for 2-3 donor organs per transplant means that less than 1% o f the insulin-dependent diabetes (IDDM)… More

New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael J. Taylor
Award Amount: $1,185,260.00
Abstract:
DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the Edmonton protocol . However, at this time, procurement of donor p ancreases for islet isolation and… More

Feasibility of Unfrozen Sub-zero Storage of Mammalian Tissues with Insect Anti-Fr

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $188,338.00
Abstract:
DESCRIPTION (provided by applicant): The long term goal is the development of better, longer hypothermic storage conditions for liver transplants than currently possible in clinical practice using novel insect antifreeze proteins. Hypothermic injury result s in vascular dysfunction during liver… More

Feasibility of Hypothermic Liver Perfusion

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $215,501.00
Abstract:
DESCRIPTION (provided by applicant): More than 43,000 Americans die each year from liver disease, making it the 10th leading disease- related cause of death in the US. Cirrhosis with irreversible injury and scarring of the liver, is the most prevalent caus e of liver failure and is attributable to… More

Controlling Intracellular Ice Formation with Antifreeze Proteins

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Lia H. Campbell
Award Amount: $203,069.00
Abstract:
DESCRIPTION (provided by applicant): Long term preservation is crucial as an enabling technology for regenerative medicine products that contain living cells. However, while cryopreservation works well for most cells, some cells are more sensitive and hard to cryopreserve by freezing. Plus, the… More

Feasibility of Unfrozen Sub-zero Storage of Mammalian Tissues with Insect Anti-Fr

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $1,762,910.00
Abstract:
DESCRIPTION (provided by applicant): The long term goal is the development of better, longer hypothermic storage conditions, using novel insect antifreeze proteins, for liver transplants than is currently possible in clinical practice. The use of hypotherm ia as the principal means to suppress… More

Assessment of MitoQ Therapy for Cold Preservation Renal Damage

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank
Award Amount: $189,552.00
Abstract:
DESCRIPTION (provided by applicant): Renal transplantation has been a clinical reality for nearly 40 years. Transplantation is the only effective solution for organ end-stage renal failure. Long term renal function following transplantation has been shown to be better when kidneys are not subjected… More

Cryopreservation of Human Epidermal Skin Models

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Lia H. Campbell
Award Amount: $160,330.00
Abstract:
DESCRIPTION (provided by applicant): In an effort to reduce the use of animals for toxicity testing, companies have developed in vitro skin models or equivalents to replace the Draize skin irritation test. This development has been further pushed by a Euro pean Union regulation that will prohibit… More

Feasibibility of deep hypothermic (18-22C) perfusion storage of livers for transp

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank – 843-514-6164
Award Amount: $185,898.00
Abstract:
DESCRIPTION (provided by applicant): More than 43,000 Americans die each year from liver disease, making it the 10th leading disease- related cause of death in the US. Cirrhosis with irreversible injury and scarring of the liver is the most prevalent causeof liver failure and is attributable to… More

Pancreas perfusion with PFC-Unisol

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Taylor – 843-722-6756
Award Amount: $312,027.00
Abstract:
DESCRIPTION (provided by applicant): There is a worldwide consensus that islet transplantation may be considered a viable option for the treatment of insulin-dependent diabetes mellitus, and clinical trials are underway at many centers around the world. Asthis approach for curing diabetes… More

Perfusion Device for Lung Evaluation and Transplantation

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank – 843-514-6164
Award Amount: $224,811.00
Abstract:
DESCRIPTION (provided by applicant): Twenty four million Americans are affected with end-stage lung disease which is the 4th leading cause of death in the US, and there are currently 2,122 candidates on the lung transplant waiting list. Emphysema and chronic obstructive pulmonary disease are the… More

Design and Assessment of a Compliant Nanofibrous Vascular Graft

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank – 843-514-6164
Award Amount: $278,179.00
Abstract:
DESCRIPTION (provided by applicant): Vascular grafting is performed clinically to repair or replace diseased coronary artery and peripheral vessels to restore normal blood flow patterns. Synthetic grafts composed of polymers such as Dacron and expanded polytetrafluoroethylene do not work well in… More

Non-Enzymatic Cryogenic Isolation of Therapeutic Cells

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Taylor – 843-722-6756
Award Amount: $268,561.00
Abstract:
DESCRIPTION (provided by applicant): In modern day medicine, cellular therapies, regenerative medicine and tissue engineering all involve technologies for harvesting, expanding, modifying and re-implanting live viable cells and tissues. Processes for preparing the therapeutic products that… More

Feasibility of immunotherapy by ice-free cryopreservation of engineered human all

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank – 843-514-6164
Award Amount: $262,005.00
Abstract:
DESCRIPTION (provided by applicant): Autologous regenerative medicine tissue therapy costs are very high because when individual tissues are manufactured all the costs fall on a single patient. Allogeneic tissues are cheaper because large tissue batches can be made and the costs are shared by many… More

Cartilage storage solution for chondrocyte viability and biomaterial preservation

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank – 843-514-6164
Award Amount: $312,642.00
Abstract:
DESCRIPTION (provided by applicant): Resurfacing of articular cartilage with cold stored osteochondral allografts is employed clinically for repair of trauma and osteoarthritis-induced articular cartilage surface damage. Chondrocyte viability of transplanted articular cartilage is accepted as one of… More

hiPS Derived Cardiomyocyte Assay for Screening Toxicant Differentiation Effects

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelvin G. Brockbank – 843-514-6164
Award Amount: $224,925.00
Abstract:
ABSTRACT Obesity is a major global health issue. According to a recent report in the Journal of the American Medical Association non-Hispanic blacks have the highest age-adjusted rates of obesity (49.5%) compared with Mexican Americans (40.4%), all Hispanics (39.1%) and non-Hispanic whites (34.3%).… More