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NEUTRALIZATION OF HIV

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7852
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
7852
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Cellular Products, Inc.
872 Main Street Buffalo, NY 14202
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1990
Title: NEUTRALIZATION OF HIV
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

MONOCLONAL ANTIBODIES HAVE BEEN GENERATED WHICH REACT WITH CONSERVED SITES OF THE P17 CORE PROTEIN OF THE HUMAN IMMUNODEFICIENCY VIRUS (HIV). TWO OF THESE ANTIBODIES EXERTA POTENT NEUTRALIZING EFFECT ON THE REPLICATION OF HIV IN PERMISSIVE CELLS. THE GOALS OF THIS PROPOSAL ARE TO (1) PRECISELY IDENTIFY THE P17 EPITOPES RECOGNIZED, (2) SYNTHESIZE PEPTIDES WHICH SPAN THE EPITOPES OF INTEREST, (3) GENERATE IDIOTYPIC REAGENTS CORRESPONDING TO THE BIOLOGICALLY ACTIVE ANTIBODIES AND TO (4) CHARACTERIZE THE ANTIPEPTIDE ANTISERA AND IDIOTYPIC ANTIBODIES FOR HIV NEUTRALIZATION AND INHIBITION OF VIRAL ADSORPTION TO TARGET RECEPTORS. METHODOLOGIES FOR ACHIEVING THESE GOALS INCLUDE EPITOPE MAPPING, PEPTIDE SYNTHESIS, MONOCLONAL AND POLYCLONAL ANTIBODY DEVELOPMENT AND THE USE OF HIV TRANSMISSION ASSAYS AND VIRAL ADSORPTION PROCEDURES. A COMPARATIVE EVALUATION OF THE BIOLOGICAL EFFICACY OF ANTIPEPTIDE VERSUS IDIOTYPIC ANTIBODIES WILL RESULT, ALONG WITH INFORMATION RELATING TO NOVEL SITES ON HIV STRUCTURES WHICH ARE AMENABLE TO NEUTRALIZATION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Cellular Products Inc.
688 Main St Buffalo, NY 14202

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No