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Surface Protein of HTLV-I

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
21882
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
21882
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Cellular Products, Inc.
872 Main Street Buffalo, NY 14202
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Surface Protein of HTLV-I
Agency: HHS
Contract: N/A
Award Amount: $29,981.00
 

Abstract:

A panel of "first generation" monoclonal antibodies (MAbs) has been developed which are directed to several distinct domains of the HTLV-1 surface protein. In addition, a sensitive chemiluminescent immunoassay has been constructed for the detection of HTLV-1 surface protein. Using monoclonal antibody affinity chromatography, gp46 will be purified from viral lysates and used as immunogen in order to develop a "second generation" panel of MAbs to native viral surface protein. Anti-gp46 MAbs will be studied for their capacity to neutralize the infectivity of HTLV- 1. The effects of MAbs on viral adsorption, cell-free transmission, and cell-to-cell infection will be investigated. The precise gp46 epitopes which react with neutralizing MAbs will be determined using peptide scanning techniques and mimetope peptides. The resulting data will support long term studies in the areas of receptor analysis, viral pathogenesis, and in the design of anti-viral modalities.

Principal Investigator:

Lawrence D. Papsidero
7168820920

Business Contact:

Small Business Information at Submission:

Cellular Products, Inc.
872 Main Street Buffalo, NY 14202

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No