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Company Information:

Company Name: CENTROSE, LLC
City: MADISON
State: WI
Zip+4: 53717-
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,232,492.00 6
STTR Phase I $75,000.00 1

Award List:

novel macrolides as anti-infective drugs

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles R. Hutchinson
Award Amount: $244,089.00
Abstract:
DESCRIPTION (provided by applicant): Although it has long been known that macrolide glycosylation is absolutely essential for antibacterial activity, the megalomicins (which differ from erythromycins solely via an additional sugar attached at C6 of the mac rolide) were the first macrolides to… More

cardiac neoglycosides as cancer drugs

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles R. Hutchinson
Award Amount: $163,192.00
Abstract:
DESCRIPTION (provided by applicant): Epidemiological evidence points to the value of cardiac glycosides like digoxin and digitoxin for treatment of breast cancer and recent reports suggest they may be especially useful to treat non-small cell lung cancer. These and other findings underlie our… More

STTR Phase I: Development of Bacterial Glycorandomization Hosts

Award Year / Program / Phase: 2008 / STTR / Phase I
Agency: NSF
Research Institution: University of Wisconsin- Madison
Principal Investigator: charles R. hutchinson, PhD
Award Amount: $75,000.00
RI Contact: Jon S. Thorson
Abstract:
This Small Business Technology Transfer Research Phase I project develops methodology needed for the production of sugar enhanced (glycosidic) compound libraries and final therapeutic leads. Sugar attachments have been identified as a powerful way to make therapeutically relevant small molecules.… More

Automation of Neoglycoside Synthesis

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles R. Hutchinson
Award Amount: $198,836.00
Abstract:
DESCRIPTION (provided by applicant): The process of small molecule and natural product glycorandomization developed by Thorson and coworkers has been validated as one of the first simple, efficient and general glycosylation strategies for small molecule an d macromolecular therapeutics. Given its… More

Amphotericin B Analogs

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles R. Hutchinson
Award Amount: $277,253.00
Abstract:
DESCRIPTION (provided by applicant): Current antifungal therapy is limited by the types of drugs available to treat systemic infections due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Crypt ococcus and the Zygomycoses. Neutropenic… More

SBIR Phase I: Development of a High Throughput Glycosyl-Scanning Platform

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: NSF
Principal Investigator: James R. Prudent
Award Amount: $150,000.00
Abstract:
This Small Business Innovation Research Phase I project highlights a strategy for the development of the first integrated high throughput pipeline to synthesize and evaluate novel sugar-drug conjugates. The core innovation of this proposed phase I study is an enzyme catalyzed one-step glycosylation… More

A new paradigm for antibody-directed conjugates

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: James R. Prudent – 608-836-0207
Award Amount: $199,122.00
Abstract:
DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is among the most common and lethal cancers yet, the current standard of care for advanced stage NSCLC provides only modest improvements in overall survival or quality of life. Thus,there exists a significant unmet need for new… More