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STTR Phase I: Development of Bacterial Glycorandomization Hosts

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
88450
Program Year/Program:
2008 / STTR
Agency Tracking Number:
0740027
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CENTROSE, LLC
802 Deming Way MADISON, WI 53717-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: STTR Phase I: Development of Bacterial Glycorandomization Hosts
Agency: NSF
Contract: 0740027
Award Amount: $75,000.00
 

Abstract:

This Small Business Technology Transfer Research Phase I project develops methodology needed for the production of sugar enhanced (glycosidic) compound libraries and final therapeutic leads. Sugar attachments have been identified as a powerful way to make therapeutically relevant small molecules. Examples of drugs with sugar attachments such as erythromycin and doxorubicin show how sugars can change inactive molecules into antibacterial or anticancer drugs. Finding the correct genetically altered cell-based systems needed for efficient high yield production of small molecule sugar enhanced compounds is the first phase at exploiting sugar enhanced drug discovery beyond what Nature has provided. The broader impacts of this research are found in the enormous potential that sugar enhancement provides to therapeutics. Sugars are critical molecules that regulate a vast array of biological processes and pathways in the human body and play fundamental roles in diseases as well as in drug action. This project will greatly expand the ease and reduce the cost of making, screening and commercially scaling sugar-enhanced small molecule therapeutics.

Principal Investigator:

charles R. hutchinson
PhD
5107015200
hutchinson@centrosepharma.com

Business Contact:

charles R. hutchinson
PhD
5107015200
hutchinson@centrosepharma.com
Small Business Information at Submission:

centrose llc
3750 Country Grove Drive Madison, WI 53719

EIN/Tax ID: 205807443
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University of Wisconsin- Madison
21 North Park Street
Suite 6401
Madison,, WI 53715 1218
Contact: Jon S. Thorson
Contact Phone: (608) 836-0207
RI Type: Nonprofit college or university