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SBIR Phase II: Development of Agents to Promote Cellular Ga-67 (Gallium-67)…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
63353
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
0320485
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CHEMICA TECHNOLOGIES, LLC
20000 NW Walker Rd Beaverton, OR -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2005
Title: SBIR Phase II: Development of Agents to Promote Cellular Ga-67 (Gallium-67) Uptake
Agency: NSF
Contract: 0450618
Award Amount: $499,992.00
 

Abstract:

This Small Business Innovation Research Phase II project focuses on the development of new pharmaceutical agents to selectively enhance tumor imaging using gallium 67. A photo-degradation product of nifedipine, nitrosipine, has been found to selectively enhance the uptake of Ga67 by tumor cells. A specific derivative of nitrosipine has an even better selective uptake of the radioactive imaging agent. This project will synthesize and test other nitrosipine derivatives and determine the efficacy of Ga67 uptake in animal models using these complexing agents. The commercial application of this technology is in the area of diagnostic imaging. The use of Ga67 in tumor imaging is currently very limited due to poor selectivity of the agent for tumor cells. Enhanced uptake in tumor cells relative to normal cells would expand the types of tumors that could be effectively imaged and possibly replace the more costly and complex PET scan imaging using radioactive fluorinated sugars.

Principal Investigator:

Takuji Tsukamoto
Dr
5413850355
taku@chemica.com

Business Contact:

Takuji Tsukamoto
Dr
5413850355
taku@chemica.com
Small Business Information at Submission:

Chemica Tech Inc
325 S.W. Cyber Drive Bend, OR 97702

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No