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A NEW APPROACH FOR ANTIGEN PRESENTATION AND POLYVALENT VACCINES IS PROPOSED.

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2909
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2909
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Chiron Corp
4560 Horton St Emeryville, CA 94608
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: A NEW APPROACH FOR ANTIGEN PRESENTATION AND POLYVALENT VACCINES IS PROPOSED.
Agency: HHS
Contract: N/A
Award Amount: $37,095.00
 

Abstract:

A NEW APPROACH FOR ANTIGEN PRESENTATION AND POLYVALENT VACCINES IS PROPOSED. EXPERIMENTS ARE DESIGNED TO TEST THE IDEA OF COMBINING THE GENE OF A SECOND IMMUNOGEN WITH THAT OF HEPATITIS B SURFACE ANTIGEN (HBSAG) SUCH THAT THE SECOND IMMUNOGEN IS ASSEMBLED INTO, AND PRESENTED ON, THE SURFACE OF THE HBSAG PARTICLE. THESE ENGINEERED GENES ARE EXPRESSED AS PARTICLES WITH HIGH EFFICIENCY BY TRANSFORMED YEAST OR MAMMALIAN CELLS. USING HYBRID HBSAG-HSV-1GD PARTICLES AS A MODEL WE PROPOSE: A.TO DEVELOP A STANDARD METHOD FOR PURIFICATION OF THE B.TO TEST IN ANIMALS THE ABILITY OF THE HYBRID PARTICLE TO INDUCE ANTIBODIES AGAINST BOTH ANTIGENS, AND C.TO TEST THESE PARTICLES AS A VACCINE IN ANIMALS FOR PROTECTION AGAINST A CHALLENGE WITH THE CORRESPONDING INFECTIOUS AGENTS. ONCE PROVEN SUCCESSFUL, THIS STRATEGY HAS WIDE GENERAL APPLICATION FOR THE MANUFACTURE OF SAFE AND EFFICACIOUS VACCINES FOR HUMAN USE.

Principal Investigator:

Pablo valenzuela
PRINCIPAL INVESTIGATOR
4156558729

Business Contact:

Small Business Information at Submission:

Chiron Corpon
4560 Horton Street Emeryville, CA 94608

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No