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"TI\PC SOFTWARE FOR ANALYZING LONGITUDINAL DATA

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16734
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
16734
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Civilized Software, Inc.
7735 Old Georgetown Road, Suit Bethesda, MD 20814
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1993
Title: "TI\PC SOFTWARE FOR ANALYZING LONGITUDINAL DATA
Agency: HHS
Contract: N/A
Award Amount: $471,953.00
 

Abstract:

WE WILL PRODUCE A PC SOFTWARE PACKAGE, CALLED TI, TAILORED TO THE ANALYSIS AND DISPLAY OF LONGITUDINAL DATA, ARGUABLY THE MOST COMMON DESIGN FOR BIOMEDICAL DATA COLLECTION. REPEATED MEASURES STUDIES MAY HAVE FROM TWO TO THOUSANDS OF OBSERVATIONS PER SUBJECT, FROM ONE TO MANY SUBJECTS, AND CONTINUOUS OR DISCRETE OUTCOMES. DATA FROM ONE SUBJECT WITH MANY, CONTINUOUS OUTCOMES IS THE CLASSICAL TIME SERIES (EX: EEG AND OTHER CORTICAL POTENTIAL MEASUREMENTS) WHILE DATA FROM MANY SUBJECTS WITH A FEW CONTINUOUS OUTCOMES (E. G., BLOOD CHEMISTRIES) OR A FEW DISCRETE OUTCOMES (E. G. SEROLOGIC TITERS) TYPIFY REPEATED MEASURES.... FOR THESE, AND MANY OTHER DESIGNS, TI'S PHASE I GRAPHICS WILL DISPLAY THE TRAJECTORY OF INDIVIDUAL SUBJECTS AND OF GROUP SUMMARIES INCLUDING OPTIONS FOR INTERACTIVE SUBSETTING. FOR INFERENCE, PHASE I WILL INCLUDE THE HIERARCHICAL LINEAR MODEL [BRYK & RAUDENBUSH, 1987] A ANALYSES FOR PAIRED (TWO TIME POINT) DATA. PHASE II WILL GREATLY EXTEND TI TO INCLUDE MANAGEMENT OF REPEATED MEASURES DATA, GRAPHICS THAT INCLUDE DISPLAY OF AND STRATIFICATION BY TIME-DEPENDENT COVARIATES (E. G., RUNNING HEMATOCRITS), AND INTERACTIVE DATA TRANSFORMATION. PHASE II MODELING OPTIONS WILL INCLUDE MARKOV CHAINS, THE GENERALIZED ESTIMATING EQUATION APPROACH OF [ZEGER, LIANG & ALBERT, 1988], OTHER QUASI-LIKELIHOOD MODELS [MCCULLAGH & NELDER, 1983] ALONG WITH A RIGOROUS TREATMENT OF MISSING DATA [LITTLE & RUBIN, 1987]. TI WILL HAVE A PLEASANT, CONSISTENT INTERFACE FOR A WIDE VARIETY OF OPTIONS AND SO WILL FACILITATE ANALYSES THAT WOULD OTHERWISE BE DONE ON AN AD HOC BASIS USING SEVERAL STATISTICAL PACKAGES.

Principal Investigator:

Bunow, Barry J
Principal Investigator
3016524714

Business Contact:

1 r43 hl47237-01
Small Business Information at Submission:

Civilized Software, Inc.
7735 Old Georgetown Road Bethesda, MD 20814

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No