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Identification of Immunogenic Components of Flavobacterium Psychrophilum for a…

Award Information

Agency:
Department of Agriculture
Branch:
N/A
Award ID:
52182
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
2001-00378
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Clear Springs Foods, Inc.
P. O. Box 712 Buhl, ID 83316
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Identification of Immunogenic Components of Flavobacterium Psychrophilum for a CWD Vaccine
Agency: USDA
Contract: 2001-33610-10373
Award Amount: $69,582.00
 

Abstract:

Coldwater disease (CWD), caused by Flavobacterium psychrophilum, results in severe losses to salmonid aquaculture worldwide. In recent years, this disease has had a significant economic impact on commercial, Federal and State aquaculture facilities in the U.S. Immunization against this disease would provide the most benefit to producers, and although significant protection has been observed under laboratory conditions, no commercial vaccines exist. This is likely due to virulence differences observed among F. psychrophilum isolates. This Phase I study will evaluate and identify immunogenic antigens of F. psychrophilum and determine the role of virulence-associated proteins in conferring antibody- mediated protection. Limited data exists on the immune response of fish to F. psychrophilum, but is considered essential to developing a vaccine to CWD. Therefore, this study will 1) evaluate antibody responses to F. psychrophilum following immunization via injection and immersion routes, 2) identify the major bacterial protein components to which an antibody response is generated, and 3) determine the importance of these antigens in protection from pathogen challenge. This will greatly increase our understanding of the immune response to this disease and provide a foundation for the development of vaccine in Phase II studies that would greatly benefit the aquaculture industry.

Principal Investigator:

Scott E. LaPatra
2085433456
scottl@clearsprings.com

Business Contact:

John R. MacMillan
Vice President, Research & Environmental
2085433456
Small Business Information at Submission:

Clear Springs Foods, Inc.
P. O. Box 712 Buhl, ID 83316

EIN/Tax ID: 820246213
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No