Identification of Candidate Genes for Prostate Cancer

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 24898	Program Year/Program: 1994 / SBIR
Agency Tracking Number: 24898	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: C-MOTION, INC.
C-MOTION, INC. 15821A CRABBS BRANCH WAY ROCKVILLE, MD 20855
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 1: Fiscal Year: 1994

Title: Identification of Candidate Genes for Prostate Cancer

Agency: HHS

Contract: 1 R43 CA65197-1,

Award Amount: $81,000.00

Abstract:
Our goal is to identify genes that play a critical role in the development of prostate cancer. Thespecific aim of Phase I is to use differential display (Liang and Pardee, 1992) to identify differentiallyexpressed genes in normal prostate and tumorigenic prostate cell lines. Differentially amplified bands willbe evaluated by hybridization to Northern blots. Viable candidate genes will be sequenced and comparedfor homology to known genes in GenBank. In addition to identifying candidate genes for prostatecancer, modifications to increase the specificity and efficiency of the differential display technique willbe tested. These will include the use of alternate primers and an assessment of the feasibility ofincorporating a subtractive hybridization step. Since prostate cancer represents the most frequent cancerin US males, an understanding of the molecular nature of the disease will have significant medicalimpact.

Principal Investigator:
Tim Keith
6174877979

Business Contact:

Small Business Information at Submission:

Collaborative Research, Inc.
1365 Main Street Waltham, MA 02154

EIN/Tax ID: 522053087

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No