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TWO CARTILAGE INDUCING FACTORS (CIF), WHICH INDUCE THE DIFFERENTIATION OF…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2948
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2948
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Collagen Corp
2500 Faber Place Palo Alto, CA 94303
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: TWO CARTILAGE INDUCING FACTORS (CIF), WHICH INDUCE THE DIFFERENTIATION OF MESENCHYMAL CELLS INTO CHONDROBLASTS IN VITRO, HAVE BEEN ISOLATED FROM BOVINE DEMINERALIZED BONE (SEYEDIN ET AL.
Agency: HHS
Contract: N/A
Award Amount: $40,275.00
 

Abstract:

TWO CARTILAGE INDUCING FACTORS (CIF), WHICH INDUCE THE DIFFERENTIATION OF MESENCHYMAL CELLS INTO CHONDROBLASTS IN VITRO, HAVE BEEN ISOLATED FROM BOVINE DEMINERALIZED BONE (SEYEDIN ET AL. PROC. NATL. ACAD. SCI. 1985). THE INDUCED CELLS SYNTHESIZE DIFFERENTIATED CHONDROCYTE MARKERS SUCH AS CARTILAGE-SPECIFIC PROTEOGLYCANS AND TYPE II COLLAGEN. INDUCTION OF CHONDROGENESIS IN RESPONSE TO CIF IS EXPECTED TO BE MEDIATED THROUGH THE FINDING OF THE CIF TO A SPECIFIC PLASMA MEMBRANE RECEPTOR FOLLOWED BY ENDOCYTOSIS OF THE CIF-RECEPTOR COMPLEX, AS IS THE CASE WITH SEVERALPOLYPEPTIDE HORMONES AND GROWTH FACTORS.THIS PROJECT IS DIRECTED TOWARD IDENTIFICATION, PURIFICATION, AND CHARACTERIZATION OF THE RECEPTOR FOR CIF. PURIFICATION AND CHARACTERIZATION OF THE CIF RECEPTOR IS ESSENTIAL TO UNDERSTAND THE MECHANISM UNDERLYING CARTILAGE INDUCTION AND DIFFERENTIATION. THE FIRST PHASE OF THIS RESEARCH WOULD INVOLVE IDENTIFICATION AND INITIAL CHARACTERIZATION OF THE RECEPTOR FOR CIF EMPLOYING 125 I-CIF AS A PROBE. PHASE II WOULD BE DIRECTED TOWARD PURIFICATION AND FURTHER CHARACTERIZATION OF CIF RECEPTOR.

Principal Investigator:

Saeid seyedin
PRINCIPAL INVESTIGATOR
4158560200

Business Contact:

Small Business Information at Submission:

Collagen Corpon
2500 Faber Pl. Palo Alto, CA 94303

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No