You are here

TWO CARTILAGE INDUCING FACTORS (CIF), WHICH INDUCE THE DIFFERENTIATION OF MESENCHYMAL CELLS INTO CHONDROBLASTS IN VITRO, HAVE BEEN ISOLATED FROM BOVINE DEMINERALIZED BONE (SEYEDIN ET AL.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2948
Amount: $40,275.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1985
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2500 Faber Pl.
Palo Alto, CA 94303
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SAEID SEYEDIN
 PRINCIPAL INVESTIGATOR
 (415) 856-0200
Business Contact
Phone: () -
Research Institution
N/A
Abstract

TWO CARTILAGE INDUCING FACTORS (CIF), WHICH INDUCE THE DIFFERENTIATION OF MESENCHYMAL CELLS INTO CHONDROBLASTS IN VITRO, HAVE BEEN ISOLATED FROM BOVINE DEMINERALIZED BONE (SEYEDIN ET AL. PROC. NATL. ACAD. SCI. 1985). THE INDUCED CELLS SYNTHESIZE DIFFERENTIATED CHONDROCYTE MARKERS SUCH AS CARTILAGE-SPECIFIC PROTEOGLYCANS AND TYPE II COLLAGEN. INDUCTION OF CHONDROGENESIS IN RESPONSE TO CIF IS EXPECTED TO BE MEDIATED THROUGH THE FINDING OF THE CIF TO A SPECIFIC PLASMA MEMBRANE RECEPTOR FOLLOWED BY ENDOCYTOSIS OF THE CIF-RECEPTOR COMPLEX, AS IS THE CASE WITH SEVERALPOLYPEPTIDE HORMONES AND GROWTH FACTORS.THIS PROJECT IS DIRECTED TOWARD IDENTIFICATION, PURIFICATION, AND CHARACTERIZATION OF THE RECEPTOR FOR CIF. PURIFICATION AND CHARACTERIZATION OF THE CIF RECEPTOR IS ESSENTIAL TO UNDERSTAND THE MECHANISM UNDERLYING CARTILAGE INDUCTION AND DIFFERENTIATION. THE FIRST PHASE OF THIS RESEARCH WOULD INVOLVE IDENTIFICATION AND INITIAL CHARACTERIZATION OF THE RECEPTOR FOR CIF EMPLOYING 125 I-CIF AS A PROBE. PHASE II WOULD BE DIRECTED TOWARD PURIFICATION AND FURTHER CHARACTERIZATION OF CIF RECEPTOR.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government