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Improved Efficiency Extracorporeal Membrane Oxygenators

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Compact Membrane Systems, Inc.
335 Water Street Newport, DE 19804-2410
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 1997
Title: Improved Efficiency Extracorporeal Membrane Oxygenators
Agency: HHS
Contract: 1 R43 HL52397-1,
Award Amount: $749,824.00


Extracorporeal life support (ECLS) is used for newborn infants with respiratory failure. Improvedlong term ECLS efficiency is desirable and would allow broader (children/adults/ cardiac support) andsafer use. Systems are based on microporous (hollow fiber) membranes or silicon non-porousmembranes. Microporous membranes have adequate initial performance but after 2-6 hours "plasmaleakage" clogs the pores and gas transport drops significantly. Silicone membranes are more stable butgas permeabilities are much lower. Also silicone is not workable. This leads to configurations withhigher priming volume and poor blood side flow and associated poor gas transport. We will developnovel high permeability perfluoropolymers into hollow fiber (HF) membranes with excellent oxygen andcarbon dioxide transport. Using thin film fabrication techniques demonstrated on related polymers wewill make HF modules with stable carbon dioxide and oxygen fluxes 20 times higher than silicone andsignificantly higher than demonstrated in non-porous ECLS operation. Phase I will demonstrate our abilityto fabricate high flux hollow fibers and project extracorporeal membrane oxygenator (ECMO)performance. In Phase II we will optimize performance, make larger HF modules, perform ECLS tests,and evaluate biocompatibility.

Principal Investigator:

Stuart Nemser

Business Contact:

Small Business Information at Submission:

Compact Membrane Systems, Inc.
325 Hampton Road Wilmington, DE 19803

Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No